CURRICULUM VITAE                    

Date: January 21, 2007

PERSONAL INFORMATION

Name:                                      NAMASIVAYAM AMBALAVANAN

Citizenship:                               United States of America

 

RANK/TITLE                        Assistant Professor, Departments of Pediatrics and Cell Biology,

Department:                              Pediatrics; Division of Neonatology

Business address:                      525 New Hillman Building       

619 South 19th St., Birmingham, AL 35233 USA 

Phone:                                      205-934-4680

Fax:                                          205-934-3100

Email:                                       ambal AT uab.edu

 

HOSPITAL AND OTHER (NON-ACADEMIC APPOINTMENTS):

1.      Medical Staff, University of Alabama at Birmingham School of Medicine

2.      Medical Staff, The Children’s Hospital of Alabama

3.        Pediatrician / Neonatologist, Jefferson Clinic P.C., Birmingham

 

PROFESSIONAL CONSULTANTSHIPS: None

 

EDUCATION:

Institution                                                       Degree                                    Year

1. Medical School

Jawaharlal Institute of PostGraduate Medical Education and Research (JIPMER)

Pondicherry, India                                            MBBS                                     1988

 

2. JIPMER

Pondicherry, India                                            Internship                                 1990

 

3. Post Graduate Institute of Medical Education and Research (PGIMER)

Chandigarh, India                                             MD (Pediatrics)                        1993

 

4. University of Alabama at Birmingham           

Birmingham, Alabama, USA                             1 yr Pediatric Residency           1996

                                                                                                3 yrs Neonatology Fellowship   1997

 

 

LICENSURE:

Licensed in the state of Alabama

Licensed to practice medicine in India -permanent license

 

CERTIFICATION

Certified in Pediatrics by American Board of Pediatrics (Oct 1996; Recertified 2003-2010)

Certified in Neonatal-Perinatal Medicine by American Board of Pediatrics (Nov 1997; Recertified 2004-2011)

Awarded MD (Pediatrics) by PGIMER, India (Silver Medalist; First in class): May 1993

 

POSTDOCTORAL TRAINING: See Education

1. Post Graduate Institute of Medical Education and Research

Chandigarh, India                                             MD (Pediatrics)                        1993

 

2. University of Alabama at Birmingham           

Birmingham, Alabama, USA                             1 yr Pediatric Residency           1996

                                                                                                3 yr Neonatology Fellowship     1997

 

ACADEMIC APPOINTMENTS:

1.      Assistant Professor, Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham (UAB): Oct 1, 2000 – present

(Approved for promotion to Associate Professor with Tenure by Department, Sept 2006)

2.      Associate Director, Division of Neonatology, University of Alabama at Birmingham (UAB): 2003 – present

3.      Director, Newborn Care Unit, Cooper Green Hospital: Oct 2001-present

4.      Assistant Professor, Department of Cell Biology, University of Alabama at Birmingham (UAB): Aug 1, 2006 – present

5.      Clinical Assistant Professor, Department of Pediatrics, Division of Neonatology, UAB: May 1, 1998 – Sept 30, 2000 (unpaid academic appointment during period of service in medically underserved county hospital)

6.      Instructor, Department of Pediatrics, Division of Neonatology, UAB: Feb 1, 1998 to Apr 30, 1998

7.      Fellow/Instructor in the Division of Neonatology, UAB: Oct 8, 1993 to Nov 7, 1997

 

AWARDS/HONORS

1.      President, Southern Society for Pediatric Research, 2005-6

2.      Young Investigator Award (Basic Science; Southern Society for Pediatric Research), 2000

3.      Grant Reviewer (Ad hoc); NICHD/NIH, 2004

4.      Grant Reviewer (Ad hoc); Raine Medical Research Foundation, 2005; PSI Foundation, Canada, 2003; Yale CreFF, 2002

5.      Chairman’s Award (Dept of Pediatrics, University of Alabama at Birmingham), May 1997

6.      Best Doctors in America, 2005-6

7.      Ross Award in Research (Southern Society of Pediatric Research), February 1997 and 1998

8.      Highest scores in USA in the general pediatrics certifying examination (770; Oct 1996) and in the neonatal-perinatal medicine certifying examination (800; Nov 1997)

9.      Medical School: Endowment prizes (first in class) in Medicine, Pediatrics, Cardiology, and Radiology; Certificates of Honor in Biochemistry, Medicine, Pediatrics, Surgery, and Cardiology

 

PROFESSIONAL SOCIETIES AND MEMBERSHIPS

Society for Pediatric Research (SPR)

Southern Society for Pediatric Research (SSPR)

American Thoracic Society (ATS)

American Academy of Pediatrics (AAP)

Jefferson County Medical Society (JCMS)

Medical Association of the State of Alabama (MASA)

 

COUNCILS AND COMMITTEES

Medical Executive Committee, Jefferson Clinic P.C./Cooper Green Hospital

Council Member, Southern Society for Pediatric Research, 2002-2004

President, Southern Society for Pediatric Research, 2005-2006

 

UNIVERSITY ACTIVITIES

Associate Director, Division of Neonatology

Fellowship Oversight Committee, Division of Neonatology

Fellowship Recruitment Committee, Division of Neonatology

Perinatal Mortality Committee, Division of Neonatology

PIN Replacement Committee (Physician Workflow Committee and Physician Advisory Committee), UAB

 

EDITORIAL BOARD MEMBERSHIPS

Journal of Medical Research and Practice (JMRP) (in development)

 

MAJOR RESEARCH INTERESTS

Basic research: Mechanisms underlying neonatal pulmonary vascular remodeling and neonatal pulmonary hypertension, in association with Dr. Yiu-Fai Chen and Dr. Suzanne Oparil of the Hypertension and Vascular Biology program at UAB, and Dr. Joanne Murphy-Ullrich of the Department of Pathology and the Cell Adhesion and Matrix Research Center. 

Clinical research: Neonatal nutrition (specifically vitamin A), feeding practices, and probiotics. In collaboration with Dr. Waldemar Carlo, director of the neonatal division at UAB and Dr. Catharine Ross of Penn State University.

Epidemiological research: prediction of neonatal outcomes, in association with Dr. Waldemar Carlo and the Research Triangle Institute (RTI)/NICHD Neonatal Research Network.

 

TEACHING EXPERIENCE

Experienced in teaching pediatrics and neonatology to medical students, residents, and fellows during my years of residency, fellowship, and post-fellowship academic work.

Resident evaluations in the past two years (2004 and 2005) have ranged from ~ 4.7-4.8 (of 5).

Teaching includes:

1)      monthly lectures to pediatric residents and medical students,

2)      Perinatal grand rounds twice per year,

3)      Pediatric grand rounds once every two years,

4)      Pediatric noon conference for pediatric residents once every two years

5)      Child Health Investigative Forums (CHIF) once every year

6)      Annual pediatric board review (neonatology topics) is also conducted once per year for PL-3 residents.

7)      PAT 702: Hughes Med-to-Grad course on Phenotyping Human Disease (Oct 2006)

 

Mentor for students in Master’s degree and Undergraduate Biology programs at UAB since 2000;

Mentor for Neonatology fellows since 2002; Mentor for PhD students since 2006 (see Mentorship section on page 17)

 

Other education-related activities:

1.      Collection of neonatology teaching files and teaching images at division website (password required): www.pedsportal.uab.edu/neonatology.htm

2.      Collection of neonatology teaching files at personal website

http://home.sprynet.com/~ambal/neonatal.htm

3.      Collection of grant-related information at website: http://www.dpo.uab.edu/~ambal/grants.htm

 

 

MAJOR LECTURES AND VISITING PROFESSORSHIPS: See invited lectures on page 16

 

GRANT SUPPORT:

 

Past

1) Ambalavanan (PI)                                                    7/1/1995-06/30/1996

Wyeth Pediatrics Neonatology Research Fund.             $ 3,400

Research proposal: “Peptide growth factors in neonatal pulmonary vascular remodeling”

 

2) Ambalavanan (PI)                                                    12/1/2001-10/31/2003

CHRC (Child Health Research Center)                         $ 50,000 Annual           50% effort

“Effects of endothelin-A receptor blockade on hypoxic pulmonary vascular remodeling”

Mentor: YF Chen Ph.D.

 

3) Ambalavanan (PI)                                                                      4/1/2003-3/31/2004     

Cell Adhesion and Matrix Research Center, UAB         $25,000 Annual            25% effort       

 “ECM Remodeling in Hypoxic Neonatal PVR”

 

4) PHA #0526041H (Ferzli)                             07/01/2005-06/30/2006           0% effort

Pulmonary Hypertension Association                 Annual funding $34,000

“Lung Assist Device in Neonatal Porcine Respiratory Failure: Effect on Pulmonary Histopathology and Lung Mechanics”

Role: Mentor/Sponsor

The major goals of this project were to test the feasibility and efficacy of reduction of lung injury using a novel lung assist device in neonatal porcine respiratory failure

 

5) UAB PHHD PG (Ambalavanan)                  08/01/2005 – 07/31/2006        0% effort

UAB Perinatal Health and Human Development Pilot Grant   Annual funding $25,000

“TGF-beta in Lung Development During Hypoxia”

Role: PI

 The major goals of this project are to determine the mechanisms by which TGF-b alters alveolar development and vascular remodeling during hypoxia in the newborn lung

 

Current

1) HD046513 (Ambalavanan)                        4/1/2004 – 3/31/2008           75% effort

NIH    K08 Mentored Clinical Scientist Development Award       Annual direct cost $107,751

“MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling”  

Role: PI                                

Mentor: Suzanne Oparil  M.D.   Co-Mentor: Joanne Murphy-Ullrich Ph.D.

Priority Score: 128

The objective of this project is to determine the mechanisms by which hypoxia alters ECM deposition during HPVR, with specific focus on the role of MMP-2 in this process.                                                                                                     

 

2) HD34216 (Carlo)                                       04/01/96 – 03/31/06                3% effort

NICHD                                                           $822,388                                 No salary support

“Multi-center Network of Neonatal Intensive Care Units”

Role: Co-investigator (Alternate PI)

The major goals of this project are to work with the NICHD and the Steering Committee to prioritize, plan, implement, analyze, interpret, and report a series of randomized and observational studies.

Current projects:

Co-PI of Probiotics in Preterm Infants trial, PI of probiotic pilot studies

Premie iNO ancillary study

Cytokine ancillary study;

 

 

3) ATS/PHA Research Grant (Ambalavanan)                     1/1/2007 – 12/31/2008

ATS/Pulmonary Hypertension Association                           Annual direct cost $50,000                                                                                                                                                                                                                                   

Regulation of TGF-Beta in Neonatal Hypoxia Induced Pulmonary Vascular Remodeling

Role: PI

Specific Aim (1) will test the hypothesis that Dominant-Negative  TGFbeta RII neonatal mice (reduced TGF-beta signaling) will have attenuation of abnormal pulmonary arterial remodeling and inhibition of alveolar development during hypoxia. Specific Aim (2) will test the hypothesis that TGF-beta activation by TSP1 is necessary and sufficient for abnormal pulmonary arterial remodeling and inhibition of alveolar development in neonatal mice. Specific Aim (3) will test the hypothesis that hypoxia-induced reductions in Thy-1 lead to TGF-beta activation in vitro and in vivo.

 

4) Ambalavanan (PI)              01/01/2006 – 12/31/2007        0% effort

Children’s Center for Research and Innovation                  Annual funding $50,000

“Transforming Growth Factor b (TGF-b) and Neonatal Lung Development in Hypoxia”

Role: PI

To major goals of this project are to test the hypotheses that hypoxia increases TSP-1, decreases Thy-1, and thereby activates TGF-b which inhibits MMP-2, leading to inhibition of alveolar development and abnormal pulmonary arterial remodeling

 

Pending

 

1) R03 HD054420-01 (Ambalavanan)                        12/1/2006 – 11/30/2008           10% effort

NICHD                                                                              Annual direct cost $50,000

“C-Reactive Protein in Extremely Low Birth Weight Neonates”  

Role: PI                                

Priority Score: 112 (Percentile 0.3)

The Specific Aims of this project are (1) to determine if ELBW infants who die or develop BPD have higher serum CRP concentrations in the first postnatal week, (2) to determine if ELBW infants who die or develop BPD have higher tracheal aspirate CRP concentrations in the first postnatal week, and (3) to determine if ELBW infants who die or develop BPD have genetic polymorphisms associated with higher serum CRP concentrations.

 

BIBLIOGRAPHY:

 

MANUSCRIPTS:

Peer-reviewed publications:

(In chronological order with earliest first):

1.      Trehan A, Singh S, Ambalavanan N, Kumar L. Valvular Heart Disease: Rheumatic or Rheumatoid?.  Indian Pediatr 34: 641- 644, 1997

2.      Rayyis SF, Ambalavanan N, Wright L, Carlo WA. Randomized trial of "Slow" vs. "Fast" feed advancements on the incidence of necrotizing enterocolitis in very low birth weight infants. J Pediatr 134:293-297, 1999

3.      Ambalavanan N, Bulger A, Philips JB III. Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells. Biol Neonate 76:311-319, 1999

4.      Ambalavanan N, Mariani G, Bulger A, Philips JB III. Role of nitric oxide in regulating neonatal porcine pulmonary artery smooth muscle cell proliferation.  Biol Neonate 76:291-300, 1999

5.      Ambalavanan N, Nelson K, Alexander G, Johnson SE, Biasini F, Carlo WA. Prediction of neurologic morbidity in extremely low birth weight infants. J Perinatol 20: 496-503, 2000

6.      Ambalavanan N, Carlo WF, Bulger A, Shi J, Philips JB III. Effect of cigarette smoke extract on neonatal porcine vascular smooth muscle cells. Tox Appl Pharmacol 170: 130-136, 2001

7.      Ambalavanan N, Bulger A, Ware J, Philips JB III. Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension. Biol Neonate 80: 74-80, 2001

8.      Carlo WF, Villamor E, Ambalavanan N, DeMey JG, Blanco CE. Chronic exposure to cigarette smoke extract impairs endothelium-dependent relaxation of chicken embryo pulmonary arteries. Biol Neonate 80:247-250, 2001

9.      Ambalavanan N, Carlo WA. Comparison of the prediction of extremely low birth weight neonatal mortality by regression analysis and by neural networks. Early Hum Dev 65:123-137, 2001

10.  Ambalavanan N, Bulger A, Ware J, St. John E, Philips JB III. Feasibility of nitric oxide administration by oxygen hood in a neonatal pulmonary hypertension. J Perinatol 22:50-56, 2002

11.  Ambalavanan N, Philips JB 3rd, Bulger A, Oparil S, Chen YF. Endothelin-A
Receptor Blockade in Porcine Pulmonary Hypertension. Pediatr Res 52:913-921, 2002

12.  Ambalavanan N, Novak ZE. Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. Pediatr Res 53:240-244, 2003

13.  Ambalavanan N, Wu TJ, Tyson JE, Kennedy KA, Roane C, Carlo WA. A comparison of three vitamin A dosing regimens in extremely premature infants. J Pediatr 142:656-61, 2003

14.  Cobb BA, Carlo WA, Ambalavanan N*. Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infants. Pediatrics 113:50-53, 2004 [*Mentor and corresponding author]

15.  Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics 114: 404-410, 2004

16.  Ambalavanan N, Kennedy K, Tyson J, Carlo WA. Survey of vitamin A supplementation for extremely low birth weight (ELBW) infants: Is clinical practice consistent with the evidence? J Pediatr 145:304-307, 2004

17.  Ambalavanan N, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodeling. Pediatr Res  57:631-636, 2005

18.  Ambalavanan N, Tyson JE, Kennedy KA, Hansen N, Vohr BR, Wright LL, Carlo WA, and the NICHD Neonatal Research Network. Vitamin A supplementation for extremely low birth Weight infants: Outcome at 18-22 months. Pediatrics 115:e249-54, 2005

19.  Ambalavanan N, Ross AC, Carlo WA. Retinol-binding protein, transthyretin, and c-reactive protein in extremely low birth weight (ELBW) infants. J Perinatol 25:714-9, 2005

20.  Ambalavanan N, Carlo W, Bobashev G, Mathias E, Poole K, Fanaroff AA, Stoll BJ, Ehrenkranz R, Wright LL. Prediction of mortality for extremely low birth weight neonates. Pediatrics 116:1367-73, 2005

21.  Chen YF, Feng JA, Li P, Xing D, Serra R, Ambalavanan N, Majid-Hassan E, Oparil S. TGF-β and ANP signaling play opposing roles in hypoxia-induced pulmonary vascular remodeling. J Appl Physiol 100:564-71, 2006. [Epub Oct 13, 2005]

22.  Ambalavanan N, Baibergenova A, Carlo WA, Saigal S, Schmidt B, Thorpe KE, and the TIPP Investigators. Early prediction of poor outcome in extremely low birth weight (ELBW) infants by classification tree analysis. J Pediatr 148:438-44, 2006

23.  Chen YF, Feng JA, Li P, Xing D, Ambalavanan N, Oparil S. Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling  Life Sci. 79:1357-65, 2006 [Epub Apr 27, 2006]

24.  Ross AC, Ambalavanan N, Zolfaghari R, Li NQ. Vitamin A combined with retinoic acid increases retinol uptake and lung retinyl ester formation in a synergistic manner in neonatal rats. J Lipid Res. 47:1844-51, 2006 [Epub May 9, 2006]

25.  Ambalavanan N, Carlo WA, Shankaran S, Bann CM, Emrich SL, Higgins RD, Tyson JE, O’Shea TM, Laptook AR, Ehrenkranz RA, Donovan EF, Walsh MC, Goldberg RN, Das A, and Follow-up Investigators for the NICHD Neonatal Research Network. Predicting outcome of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics 118: 2084-93, 2006

26.  Ross AC, Ambalavanan N. Dexamethasone does not antagonize the increase in retinyl esters in the lungs of neonatal rats treated with vitamin A combined with retinoic acid (VARA). Neonatology (in press)

27.  Fabres J, Carlo WA, Phillips V, Howard G, Ambalavanan N*. Both extremes of arterial carbon dioxide pressure and the magnitude of fluctuations in arterial carbon dioxide pressure are associated with severe intraventricular hemorrhage in preterm infants. Pediatrics (in press) [*Mentor and corresponding author]

28.  Ambalavanan N, Li P, Bulger A, Murphy-Ullrich J, Anderson PG, Oparil S, Chen YF. Endothelin –1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung. Pediatr Res (in press)

 

Submitted:

1.      Broitman E, Ambalavanan N*, Higgins R, Das A, Bhaskar B, Murray K, Vohr BR, Shankaran S, Hintz S, Carlo WA for the NICHD Neonatal Research Network. Head ultrasound for prediction of neurodevelopmental outcome in preterm infants. J Pediatr (Accepted pending revisions) [*corresponding author]

2.      Ambalavanan N, Li P, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. Effects of hypoxia on the newborn mouse lung: the role of MMP-2. J Appl Physiol (in revision)

3.      Ambalavanan N, El-Ferzli GT, Roane C, Carlo WA. Nitric oxide administration using an oxygen hood: A pilot trial.

4.      Ambalavanan N, Van Meurs KP, Perritt P, Carlo WA, Ehrenkranz RA, Stevenson D, Lemons JA, Poole WK, Higgins RD, for the NICHD Neonatal Research Network. Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure.

5.      James ML, Ross AC, Bulger A, Philips JB III, Ambalavanan N*. Vitamin A and retinoic acid act synergistically to reduce hyperoxic lung injury in newborn mice. [*corresponding author]

 

In preparation:

1.      El-Ferzli GT, Philips JB III, Bulger A, Ambalavanan N. A novel lung assist device reduces pulmonary arterial pressures and improves oxygenation in a neonatal porcine model of pulmonary hypertension.

2.      Ambalavanan N, Li P, Bulger A, Murphy-Ullrich J, Hagood JS, Oparil S, Chen YF. Inhibition of TGF-beta signaling attenuates neonatal hypoxia-induced pulmonary arterial remodeling but not right ventricular hypertrophy or inhibition of alveolar development.

3.      Ambalavanan N, Hagood JS, Li P, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. A reduction in Thy-1 due to hypoxia contributes to hypoxia-induced inhibition in alveolar development.

 

Non peer-reviewed publications (Medline-indexed in bold)

1.      Ambalavanan N, Carlo WA. Current approaches to mechanical ventilation. Tufts University School of Medicine and Floating Hospital for Children Reports on: Neonatal Respiratory Diseases. Volume 8, No. 2, 1998 [review]

2.      Ambalavanan N, Carlo WA. How would you handle these newborns? Contemporary Pediatrics 16(6): 115-133, 1999

3.      Carlo WA, Ambalavanan N. Conventional Mechanical Ventilation: Traditional and New Strategies. Pediatr Rev 20(12):e117-e126, 1999 [review]

4.      Ambalavanan N, Carlo WA. Analgesia for ventilated neonates: Where do we stand? J Pediatr 135:403-405, 1999 [editorial]

5.      Ambalavanan N, Carlo WA. Hypocapnia and hypercapnia in respiratory management of newborn infants. Clin Perinatol 28(3):517-531, 2001 [review]

6.      Ambalavanan N. Recent advances in fluid management. Journal of Neonatology 16 (1): 59-65, 2002 [review]

7.      Ambalavanan N, Whyte R. The mismatch between evidence and practice: common therapies in search of evidence. Clin Perinatol 30:305-331, 2003

8.      Ambalavanan N, Carlo WA. Bronchopulmonary dysplasia: new insights. Clin Perinatol 31:613-628, 2004 [review]

9.      Ambalavanan N, Toms R. Permissive hypercapnia during mechanical ventilation of neonates. Indian Pediatrics 41:775-778, 2004. [editorial]

10.  Carlo WA, Prince LS, St John EB, Ambalavanan N. Care of very low birth weight infants with respiratory distress syndrome: an evidence-based review. Minerva Pediatr. 56:373-80, 2004 [review]

11.  Ambalavanan N. Surfactant therapy. Indian Journal of Practical Pediatrics 7(3):192-200, 2005 [review]

12.  Shuford-Hopkins E, Bulger A, Ambalavanan N, Philips JB 3rd. Doxycycline inhibits matrix metalloproteinase-2 (MMP-2) production by neonatal pulmonary artery endothelial cells. Ethn Dis. 15(3 Suppl 4):S4-98-9, Summer 2005

13.  Ambalavanan N, Carlo WA. Ventilatory strategies in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol 30:192-9, 2006 [review]

14.  Ambalavanan N. Endothelin-A receptor blockade inhibits the effects of hypoxia on the newborn lung vasculature. ScientificWorldJournal. 6:669-70, 2006 [review]

 

Other Publications:

 

BOOKS:

Books and Book Chapters

1.      Ambalavanan N, Mariani G, Philips JB III: Role of Peptide Growth Factors in Cardiovascular Development. In Polin RA, Fox WW (Eds): Fetal and Neonatal Physiology, ed 2. WB Saunders Co, Philadelphia, PA, 1997, pp 814-826

2.      Waldemar Carlo, Namasivayam Ambalavanan, Robert Chatburn: Section IV: Mechanical Ventilation. Chapter 15: Basic Principles of Mechanical Ventilation, Chapter 16: Classification of Mechanical Ventilation Devices, Chapter 17: Ventilator Parameters. In Sinha SK, Donn SM (Eds): Manual of Neonatal Respiratory Care. Futura Publishing Company, Inc., Armonk, New York, USA, 2000

3.      Waldemar A Carlo, Namasivayam Ambalavanan: Wentylacja Mechaniczna (Mechanical ventilation [Polish] ). In Gadzinowski J, Vidyasagar D (Eds): Neonatologia. Osrodek Wydawnictw Naukowych. Poznan, 2000, pp 287-301

4.      Namasivayam Ambalavanan, Waldemar Carlo: Meconium Aspiration Syndrome. In Burg FD, Ingelfinger JR, Polin RA, Gershon AA (Eds): Gellis and Kagan’s Current Pediatric Therapy. WB Saunders Co., Philadelphia, PA, 2002, pp 265-268

5.      Namasivayam Ambalavanan, Schelonka RL, Carlo WA: Ventilatory Strategies. In Goldsmith JP, Karotkin EH (Eds). Assisted ventilation of the neonate. 4th Edition. WB Saunders Co, Philadelphia, PA, 2003, pp 249-259

 

Published abstracts:

 (65 of 69 accepted for presentation: all except 14, 23, 47, 48):

1.      Ambalavanan N, Philips JB IV, Bulger A, Philips JB III: The Effect of pH on Neonatal Pulmonary Artery Smooth Muscle and Endothelial Cell Proliferation.  J Investig Med  43(1): 44A, Feb 1995

2.      Ambalavanan N, Bryant L, Bulger A, Philips JB III: Nitric oxide donors inhibit neonatal pulmonary artery smooth muscle cell proliferation. Pediatr Res 37(4): 324 A, April 1995

3.      Ambalavanan N, Bulger A, Philips JB III: Hypoxia increases vascular endothelial growth factor production by neonatal pulmonary artery smooth muscle cells. Pediatr Res 37(4): 324 A, April 1995

4.      Ambalavanan N, Bulger A, Philips JB III: The effect of pH on neonatal pulmonary artery smooth muscle and endothelial cell proliferation.  Pediatr Res 37(4): 325 A, April 1995

5.      Ambalavanan N, Bulger A, Philips JB III: Does a heme protein regulate hypoxia-mediated changes in neonatal pulmonary artery smooth muscle cell proliferation?  J Investig Med 45(1): 67A, Jan 1997

6.      Ambalavanan N, Bulger A, Philips JB III: Hypoxia-mediated release of peptide growth factors from neonatal pulmonary artery smooth muscle cells.  J Investig Med 45(1): 21A, Jan 1997

7.      Ambalavanan N, Bulger A, Philips JB III: Hypoxia-mediated release of peptide growth factors from neonatal pulmonary artery smooth muscle cells.  Pediatr Res  41(4): 245A, April 1997

8.      Ambalavanan N, Bulger A, Philips JB III: Does a heme protein regulate hypoxia-mediated changes in neonatal pulmonary artery smooth muscle cell proliferation?  Pediatr Res 41(4): 244A, April 1997

9.      Ambalavanan N, Bulger A, Philips JB III: Regulation of neonatal pulmonary artery smooth muscle cell proliferation by nitric oxide. Pediatr Res  41(4): 244A, April 1997

10.  Mariani G, Ambalavanan N, Bulger A, Philips JB III: Prostaglandin E1 and peptide growth factors stimulate neonatal pulmonary artery smooth muscle cell proliferation in a synergistic manner. Pediatr Res  41(4): 260A, April 1997

11.  Rayyis S, Ambalavanan N, Wright L, Carlo WA: Randomized trial of “Slow” versus “Fast” feeding advancement in very low birthweight infants. Pediatr Res  41(4): 172A, April 1997

12.  Ambalavanan N, Bulger A, Philips JB III: Hypoxia-inducible factor-1 (HIF-1) does not mediate hypoxic inhibition of neonatal pulmonary artery smooth muscle cell proliferation. J Investig Med 46(1): 23A, Jan 1998

13.  Ambalavanan N, Bulger A, Philips JB: Hypoxia-mediated alterations of signal transduction pathways in neonatal pulmonary artery smooth muscle cells. Pediatr Res 43(4): 273A, April 1998

14.  Ambalavanan N, Carlo WA: Prediction of mortality in ELBW infants using logistic and linear regression versus neural networks. Pediatr Res 43(4): 205A, April 1998

15.  Ambalavanan N, Nelson K, Alexander G, Carlo WA: Prediction of neurologic morbidity and its determinants in ELBW infants. Pediatr Res 43(4): 205A, April 1998

16.  Carlo WF, Ambalavanan N, Bulger A, Philips JB III: The effect of cigarette smoke extract on neonatal pulmonary artery smooth muscle cell proliferation. J Investig Med 47(2): 141A, Feb 1999

17.  Ambalavanan N, Carlo WF, Bulger A, Shi J, Philips JB III: Cigarette smoke extract causes non-apoptotic cell death in neonatal vascular smooth muscle cells. Pediatr Res 45(4):294A, Apr 1999

18.  Ambalavanan N, Carlo WA: Prediction of extremely low birth weight (ELBW) neonatal mortality by neural networks and logistic regression. Pediatr Res: 236A, Apr 1999

19.  Philips JB, Ambalavanan N, Ware J, Bulger A, Lin B, Pritchard DG: Group B Streptococcal Hyaluronidase Does Not Increase Systemic Bacterial Invasion in a Neonatal Rat Pup Model. Pediatr Res 272A, Apr 1999

20.  Ambalavanan N, Bulger A, Ware J, St.John E, Philips JB III: Nitric oxide administration by oxygen hood in neonatal pulmonary hypertension. J Investig Med 48(1): 134A, Jan 2000

21.  Ambalavanan N, Bulger A, Ware J, Philips JB III: ATP-gated potassium channels in neonatal pulmonary hypertension. J Investig Med 48(1): 152A, Jan 2000

22.  Carlo WF, Villamor EI, Ambalavanan N, DeMey JG, Blanco C: Chronic exposure to cigarette smoke extract impairs endothelium-dependent vasodilation of chick embryo pulmonary arteries. Pediatr Res Pediatr Res 47(4): 353A, Apr 2000

23.  Ambalavanan N, Bulger A, Ware J, Philips JB III: ATP-gated potassium channels in neonatal pulmonary hypertension. Pediatr Res 47(4): 350A, Apr 2000

24.  Ambalavanan N, Bulger A, Ware J, St.John E, Philips JB III: Nitric oxide administration by oxygen hood in neonatal pulmonary hypertension. Pediatr Res 47(4): 350A, Apr 2000

25.  Haberman B, Donovan E, Ambalavanan N, Hansen N, Vohr B, and the NICHD Neonatal Research Network Follow-up Subcommittee: Follow-up Compliance of Newborn Intensive Care Unit (NICU) Survivors. Pediatr Res 47(4): 312A, Apr 2000

26.  Ambalavanan N, A Bulger, TJ Wu, JB Philips, III: Retinol induces apoptosis and release of basic FGF from neonatal pulmonary endothelial and smooth muscle cells. J Investig Med 49(1): 129A, Jan 2001

27.  Ambalavanan N, A Bulger, J Ware, YF Chen, JB Philips, III: Endothelin –A receptor blockade in neonatal pulmonary hypertension. J Investig Med 49(1): 129A, Jan 2001

28.  Teng RJ, A Bulger, Ambalavanan N, JB Philips III, JS Beckman: Nitrotyrosine affects growth and protein expression of pulmonary artery endothelial cells. J Investig Med 49(1): 128A, Jan 2001

29.  Ambalavanan N, A Bulger, J Ware, YF Chen, J B Philips, III: Endothelin-A receptor blockade in neonatal pulmonary hypertension. Pediatr Res 49 (4):269A, Apr 2001

30.  Ambalavanan N, A Bulger, TJ Wu, J B Philips, III: Retinol induces apoptosis and release of peptide growth factors from neonatal lung cells. Pediatr Res 49 (4):269A, Apr 2001

31.  Panyavudhikrai S, A Bulger, N Ambalavanan, RJ Teng, JB Philips: Effect of dexamethasone on endothelial nitric oxide synthase (eNOS) levels in hypoxic pulmonary artery endothelial cells. Pediatr Res 49 (4):283 A, Apr 2001

32.  Ambalavanan N, W A Carlo, J Roayaei, LL Wright, AA Fanaroff, BJ Stoll, RA Ehrenkranz, K Poole: Prediction of mortality in extremely low birth weight (ELBW) infants. Pediatr Res 49 (4):316A, Apr 2001

33.  Ambalavanan N, Z Novak: Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. J Investig Med 50 (1): 130A, Jan 2002

34.  Ambalavanan N, TJ Wu, JE Tyson, KA Kennedy, C Roane, WA Carlo: A randomized controlled trial of three vitamin A dosing regimens in extremely low birth weight infants. Pediatr Res 51(4): 339A, Apr 2002

35.  Panyavudhikrai S, A Bulger, N Ambalavanan, RJ Teng, JB Philips, III: Effect of dexamethasone on endothelin-1 production by resistance pulmonary artery endothelial cells during normoxia and hypoxia. Pediatr Res 51(4): 357A, Apr 2002

36.  Ambalavanan N, Z Novak: Peptide Growth Factors In Tracheal Aspirates Of Mechanically Ventilated Preterm Neonates. Am J Resp Crit Care Med 165(8): A646, Apr 2002

37.  Ambalavanan N, A Bulger, YF Chen, S Oparil, J Murphy-Ullrich, J Engler: Endothelin-A receptor blockade in neonatal hypoxic pulmonary vascular remodeling. J Investig Med 51:S291, Feb 2003

38.  James ML, A Bulger, JB Philips III, N Ambalavanan: Mechanisms of apoptosis induced by retinoic acid in neonatal resistance pulmonary artery smooth muscle cells. J Investig Med 51:S291, Feb 2003

39.  Tanner J, A Novak, N Ambalavanan: Matrix metalloproteinase-2 (MMP-2) in relation to bronchopulmonary dysplasia. J Investig Med 51:S292, Feb 2003

40.  Cobb BA, WA Carlo, N Ambalavanan: Feeding intolerance and its relationship to necrotizing enterocolitis (NEC) in very low birth weight infants. J Investig Med 51:S309-310, Feb 2003

41.  Oniah LN, N Ambalavanan, A Bulger: Development of a chicken embryo model to simulate effects of maternal diabetes. J Investig Med 51:S310, Feb 2003

42.  Ambalavanan N, K Kennedy, J Tyson, WA Carlo: Vitamin A supplementation in extremely low birth weight (ELBW) infants: prevalence and factors inhibiting its widespread use. Pediatr Res 53(4): 371A, April 2003

43.  Cobb BA, WA Carlo, N Ambalavanan: Feeding intolerance and its relationship to necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. Pediatr Res 53(4): 383A, April 2003

44.  Dimmitt RA, BA Cobb, RL Schelonka, N Ambalavanan: Analysis of risk factors for necrotizing enterocolitis. Pediatr Res 53(4): 383A, April 2003

45.  Tanner JM, N Ambalavanan, RL Schelonka: Combined immunodeficiency attenuates murine hyperoxic lung injury. Pediatr Res 53(4): 401A, April 2003

46.  Tanner JM, N Ambalavanan: Matrix metalloproteinase-2 (MMP-2) in relation to bronchopulmonary dysplasia. Pediatr Res 53(4): 411A, April 2003

47.  Broitman EA, D Young, K Nelson, WA Carlo, N Ambalavanan: Prediction of poor neurologic outcome in VLBW infants with Grade IV IVH. Pediatr Res 53(4): 470A, April 2003

48.  Teng RJ, N Ambalavanan, TJ Wu, A Bulger, JB Philips: Superoxide and NO are both required for nitrotyrosine-mediated apoptosis of pulmonary artery endothelial cells. Pediatr Res 53(4): 510A, April 2003

49.  Ambalavanan N, A Bulger, J Murphy-Ullrich, J Engler, YF Chen, S Oparil: Endothelin-A receptor blockade prevents and reverses neonatal hypoxic pulmonary vascular remodeling. Pediatr Res 53(4): 431A, April 2003

50.  Ambalavanan N, A Bulger, J Windsor, J Engler, J Murphy-Ullrich, YF Chen, S Oparil: Hypoxia increases matrix metalloproteinase-2 in the neonatal pulmonary vasculature. Pediatr Res 53(4): 431A, April 2003

51.     Ambalavanan N, AC Ross, WA Carlo. Transthyretin and the Retinol Binding Protein / Transthyretin Molar Ratio in Extremely Low Birth Weight (ELBW) Infants. Pediatr Res 55(4): 443A, April 2004

52.  Broitman E, N Ambalavanan, R Higgins, A Das, B Bhaskar, K Murray, B Vohr, S Shankaran, S Hintz, W Carlo. Cranial Ultrasound Closer to 36 Weeks but Not in the First 28 Days When Combined with Clinical Variables Is Predictive of Long-Term Neurodevelopmental Outcome. Pediatr Res 55(4): 370A, April 2004

53.  Ambalavanan N, A Baibergenova, WA, Carlo, S Saigal, B Schmidt, KE Thorpe, the TIPP Investigators. Early Prediction of Poor Outcome in Extremely Low Birth Weight (ELBW) Infants by Classification and Regression Tree Analysis. Pediatr Res 55(4): 478A, April 2004

54.  Ambalavanan N, AC Ross, WA Carlo. C-Reactive Protein Predicts Death/BPD in Extremely Low Birth Weight (ELBW) Infants. Pediatr Res 55(4): 499A, April 2004

55.  Ambalavanan N, A Bulger, J Murphy-Ullrich, PG Anderson, S Oparil, YF Chen. Stimulatory Effect of Chronic Hypoxia on Extracellular Matrix Molecule Expression in the Neonatal Mouse Lung Is Partially Dependent on Endothelin-1 (ET-1). Pediatr Res 55(4): 499A, April 2004

56.  Ambalavanan N, JE Tyson, KA Kennedy, N Hansen, BR Vohr, LL Wright, WA Carlo, for the NICHD Neonatal Research Network. Does Vitamin A Supplementation Affect Long-Term Neurodevelopment in Extremely Low Birth Weight (ELBW) Infants? Pediatr Res 55(4): 504A, April 2004

57.  Ambalavanan N, J Murphy-Ullrich, A Bulger, S Oparil, Y-F Chen. Matrix Metalloproteinase-2 Contributes to Pulmonary Alveolar Development and is Essential for Pulmonary Arterial Remodeling in the Newborn Mouse. [presented at Pediatric Academic Societies’ Meeting 2005]

58.  Ambalavanan N, J Murphy-Ullrich, A Bulger, S Oparil, Y-F Chen. Fibronectin Decreases with Chronic Hypoxia in Neonatal Mouse Lung but Increases in Adult Mouse Lung. [presented at Pediatric Academic Societies’ Meeting 2005]

59.  Ambalavanan N, C Roane, WA Carlo. A Masked Randomized Controlled Feasibility Trial of Nitric Oxide Administration by Oxygen Hood. [presented at Pediatric Academic Societies’ Meeting 2005]

60.  James M L, AC Ross, A Bulger, N Ambalavanan. Synergistic Effect of Vitamin A and Retinoic Acid in Reducing Neonatal Hyperoxic Lung Injury. [presented at Pediatric Academic Societies’ Meeting 2005]

61.  Fabres JG, N Ambalavanan, V Phillips, G Howard, WA Carlo. PaCO2 Levels and Intraventricular Hemorrhage in Preterm Infants[presented at Pediatric Academic Societies’ Meeting 2005]

62.  El-Ferzli GT, N Ambalavanan, A Bulger, JB Philips III. A Novel Gas Exchange Assist Device in a Model of Neonatal Pulmonary Hypertension [presented at Pediatric Academic Societies’ Meeting 2005]

63.  J Gee, N Ambalavanan, J Gould, WA Carlo. Mortality and Morbidities in Very Low Birth Weight Infants by Month of Birth in an Academic Neonatal Intensive Care Unit [presented at Pediatric Academic Societies’ Meeting 2005]

64.  Ambalavanan N, Van Meurs KP, the NICHD NRN. Predictors of Death/BPD in Preterm Infants with Respiratory Failure[presented at Pediatric Academic Societies’ Meeting 2006]

65.  Ambalavanan N, Shankaran S, Hypothermia Subcommittee of the NICHD NRN. A Scoring System for Neonatal Hypoxic-Ischemic Encephalopathy (HIE) [presented at Pediatric Academic Societies’ Meeting 2006]

66.  Ambalavanan N, Shankaran S, Hypothermia Subcommittee of the NICHD NRN. Prediction of Prognosis in Neonatal Hypoxemic-Ischemic Encephalopathy (HIE) by Classification and Regression Tree (CART) Analysis) [presented at Pediatric Academic Societies’ Meeting 2006]

67.  El-Ferzli GT, Ambalavanan N, Bulger A, Philips JB III. A Novel Gas Exchange Assist Device in Juvenile Porcine Acute Lung Injury[presented at Pediatric Academic Societies’ Meeting 2006]

68.     Ambalavanan N, Hagood JS, MacEwen MW, Murphy-Ullrich J, Oparil S, Chen Y-F. Thy-1 Deficiency Leads to Increased TGF-beta Activation and a Delay in Alveolar Development. (presented at American Thoracic Society Meeting, 2006)

69.     Ambalavanan N, Hagood JS, Murphy-Ullrich J, Bulger A, Oparil S, Chen Y-F. Inhibition of TGF-Beta Receptor Signaling Attenuates Neonatal Hypoxia-Induced Pulmonary Arterial Remodeling (accepted for American Thoracic Society Meeting, 2007)

 

Poster exhibits (only first author posters listed):

1.      Nitric oxide donors inhibit neonatal pulmonary artery smooth muscle cell proliferation: SPR, San Diego, CA, May 1995

2.      Hypoxia increases vascular endothelial growth factor production by neonatal pulmonary artery smooth muscle cells: SPR, San Diego, CA, May 1995

3.      The effect of pH on neonatal pulmonary artery smooth muscle and endothelial cell proliferation: SPR, San Diego, CA, May 1995

4.      Hypoxia-mediated release of peptide growth factors from neonatal pulmonary artery smooth muscle cells: PAS (Pediatric Academic Societies Annual Meeting), Washington, DC, May 1997

5.      Does a heme protein regulate hypoxia-mediated changes in neonatal pulmonary artery smooth muscle cell proliferation?: PAS (Pediatric Academic Societies Annual Meeting), Washington, DC, May 1997

6.      Regulation of neonatal pulmonary artery smooth muscle cell proliferation by nitric oxide: PAS (Pediatric Academic Societies Annual Meeting), Washington, DC, May 1997

7.      Prediction of neurologic morbidity and its determinants in ELBW infants: PAS (Pediatric Academic Societies Annual Meeting), New Orleans, LA, May 1998

8.      Hypoxia-mediated alterations of signal transduction pathways in neonatal pulmonary artery smooth muscle cells: PAS (Pediatric Academic Societies Annual Meeting), New Orleans, LA, May 1998

9.      Cigarette smoke extract causes non-apoptotic cell death in neonatal vascular smooth muscle cells: PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 1999

10.  Nitric oxide administration by oxygen hood in neonatal pulmonary hypertension. PAS (Pediatric Academic Societies Annual Meeting), Boston, MA, May 2000

11.  Endothelin-A receptor blockade in neonatal pulmonary hypertension. PAS (Pediatric Academic Societies Annual Meeting), Baltimore, MD, April-May 2001

12.  Retinol induces apoptosis and release of peptide growth factors from neonatal lung cells. PAS (Pediatric Academic Societies Annual Meeting), Baltimore, MD, April-May 2001

13.  A randomized controlled trial of three vitamin A dosing regimens in extremely low birth weight infants. PAS (Pediatric Academic Societies Annual Meeting), Baltimore, MD, May 2002

14.  Peptide Growth Factors In Tracheal Aspirates Of Mechanically Ventilated Preterm Neonates. ATS (American Thoracic Society), Atlanta, GA, May 2002

15.  Endothelin-A receptor blockade prevents and reverses neonatal hypoxic pulmonary vascular remodeling. PAS (Pediatric Academic Societies Annual Meeting), Seattle, WA, May 2003

16.  Hypoxia increases matrix metalloproteinase-2 in the neonatal pulmonary vasculature. PAS (Pediatric Academic Societies Annual Meeting), Seattle, WA, May 2003

17.     Transthyretin and the Retinol Binding Protein / Transthyretin Molar Ratio in Extremely Low Birth Weight (ELBW) Infants. PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 2004

18.  Early Prediction of Poor Outcome in Extremely Low Birth Weight (ELBW) Infants by Classification and Regression Tree Analysis. PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 2004

19.  C-Reactive Protein Predicts Death/BPD in Extremely Low Birth Weight (ELBW) Infants. PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 2004

20.     Stimulatory Effect of Chronic Hypoxia on Extracellular Matrix Molecule Expression in the Neonatal Mouse Lung Is Partially Dependent on Endothelin-1 (ET-1). PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 2004

21.     Matrix Metalloproteinase-2 Contributes to Pulmonary Alveolar Development and is Essential for Pulmonary Arterial Remodeling in the Newborn Mouse. [poster symposium] Pediatric Academic Societies’ Meeting, Washington, DC, May 2005

22.  Fibronectin Decreases with Chronic Hypoxia in Neonatal Mouse Lung but Increases in Adult Mouse Lung. Pediatric Academic Societies’ Meeting, Washington, DC, May 2005

23.  A Masked Randomized Controlled Feasibility Trial of Nitric Oxide Administration by Oxygen Hood. Pediatric Academic Societies’ Meeting, Washington, DC, May 2005

24.  Predictors of Death/BPD in Preterm Infants with Respiratory Failure. Pediatric Academic Societies’ Meeting, San Francisco,CA, Apr-May 2006

25.  A Scoring System for Neonatal Hypoxic-Ischemic Encephalopathy (HIE). Pediatric Academic Societies’ Meeting, San Francisco,CA, Apr-May 2006

26.     Prediction of Prognosis in Neonatal Hypoxemic-Ischemic Encephalopathy (HIE) by Classification and Regression Tree (CART) Analysis. Pediatric Academic Societies’ Meeting, San Francisco,CA, Apr-May 2006

 

Oral Presentations (only first author presentations listed):

            National/International

1.         Prediction of extremely low birth weight (ELBW) neonatal mortality by neural networks and logistic regression: SPR 1999 (Pediatric Academic Societies Annual Meeting), San Francisco, CA.

2.         Prediction of mortality in extremely low birth weight (ELBW) infants. SPR 2001 (Pediatric Academic Societies Annual Meeting), Baltimore, MD.

3.         Does Vitamin A Supplementation Affect Long-Term Neurodevelopment in Extremely Low Birth Weight (ELBW) Infants? PAS 2004 (Pediatric Academic Societies Annual Meeting), San Francisco, CA

4.         Thy-1 deficiency leads to increased TGF-beta activation and a delay in alveolar development. (American Thoracic Society Meeting, May 2006; MiniSymposium on Molecular Mechanisms of Lung Development)

 

           

Local/Regional

1.                  The Effect of pH on Neonatal Pulmonary Artery Smooth Muscle and Endothelial Cell Proliferation: SSPR 1995 (Southern Society of Pediatric Research) (New Orleans, LA)  Awarded the “Trainee travel award”.

2.                  Hypoxia-mediated release of peptide growth factors from neonatal pulmonary artery smooth muscle cells: SSPR 1997, New Orleans, LA.  Finalist for the Basic Science Young Investigator award.

3.                  Hypoxia-mediated alterations of signal transduction pathways in neonatal pulmonary artery smooth muscle cells: SSPR 1998, New Orleans, LA.  Finalist for the Basic Science Young Investigator award.

4.                  Nitric oxide donors inhibit neonatal pulmonary artery smooth muscle cell proliferation:  Mead Johnson Southeastern Conference on Perinatal Research  (Islamoralda, Florida) March 1995

5.                  Nitric oxide donors inhibit neonatal pulmonary artery smooth muscle cell proliferation: Alabama Academy of Sciences 72nd annual meeting, UAB, March 16, 1995

6.                  Hypoxia increases vascular endothelial growth factor production by neonatal pulmonary artery smooth muscle cells: Alabama Academy of Sciences 72nd annual meeting, UAB, March 16, 1995

7.                  Nitric oxide administration by oxygen hood in neonatal pulmonary hypertension: SSPR 2000 (New Orleans. LA). Awarded the Basic Science Young Investigator award.

8.                  ATP-gated potassium channels in neonatal pulmonary hypertension: SSPR 2000 (New Orleans. LA).

9.                  Retinol induces apoptosis and release of basic FGF from neonatal pulmonary endothelial and smooth muscle cells. SSPR 2001 (New Orleans. LA).

10.              Endothelin –A receptor blockade in neonatal pulmonary hypertension. SSPR 2001 (New Orleans. LA).

11.              Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. SSPR 2002 (New Orleans. LA).

12.              Endothelin-A receptor blockade in neonatal hypoxic pulmonary vascular remodeling. SSPR 2003 (New Orleans. LA).

 

Invited workshops

1.                                          Workshop on Neonatal Ventilation. BIRDEM, Dhaka, Bangladesh. February 03-06, 2003.

2.                                          Workshop on Neonatal Ventilation. Neonatal Unit, Dept of Pediatrics, PGIMER, Chandigarh, India. February 7-9, 2003

3.                                          Workshop on Neonatal Ventilation. Vijaya Health Centre, Chennai (Madras), India. February 12, 2003

4.                                          NICHD/FDA Newborn Drug Development Initiative (NDDI) Workshop. Baltimore, MD. March 29-30, 2004.

5.                                          NICHD Improving Pediatric Therapeutics Through the Best Pharmaceuticals for Children Act of 2002. Washington, DC. May 16, 2005

 

Invited lectures/moderator at international courses and meetings

1.      Invited lectures on “Mechanical Ventilation in Respiratory Distress Syndrome” and “High Frequency Ventilation in PPHN”. 1er. Congreso Magno Internacional de Neonatologia de la Clinicia de Especialidades de la Mujer. Mexico City, Mexico. Nov 14-16, 2001.

2.      Invited lectures on “New Advances in Neonatal Resuscitation”, “The Term Neonate with Respiratory Distress”, and “Kernicterus: A Re-emerging Problem?”. 80 Simposio Internacional de Actualización Pediátrica Dr. Carlos Gianantonio. Buenos Aires, Argentina. May 22-24, 2003

3.      Invited lecture on “Surfactant therapy”. IIIrd National CME Programme in Neonatology. New Delhi, India. Oct 10-12, 2003

4.      Moderator for session on “Bronchopulmonary Dysplasia: Clinical and Experimental Insights” at the Pediatric Academic Societies’(PAS) meeting, San Francisco, CA. May 2004

5.      Moderator for session on “Neonatal Medicine: Clinical Trials I” at the Pediatric Academic Societies’(PAS) meeting, San Francisco, CA. Apr-May 2006

6.      Invited lecture on “Persistent Pulmonary Hypertension of the Newborn”. Regional Pediatric Conference, Fuzhou, China. November 8, 2006

7.      Invited lecture on “Persistent Pulmonary Hypertension of the Newborn”. Conference of Chinese Neonatologists, Shanghai, China. November 10, 2006

 

 

Invited lectures/moderator at local/regional courses and meetings (does not include local pediatric and perinatal grand rounds of which there are one to two every year)

1.                  Principles of neonatal mechanical ventilation. First Coast Symposium, Jacksonville, FL. May 11, 1998.

2.                  Gentle ventilation of the neonate. Collaborative Neonatal-Perinatal Educational Conference, New York University School of Medicine, New York, NY. June 18, 1999

3.                  Pain management and sedation in the NICU. 4th Annual Midwest Critical Care Symposium for Neonatology, Children’s Hospital Medical Center, Cincinnati, OH. Nov 11, 2000

4.                  Moderator for session on Pulmonary Hypertension at “Vascular Biology and Hypertension 15th Annual Symposium” organized by the Vascular Biology and Hypertension Program at UAB, Destin, FL. October 7-10, 2004

5.                  Effects of hypoxia on the vasculature and extracellular matrix of the newborn lung. Cell Adhesion and Matrix Research Seminar. UAB, Birmingham, AL. December 14, 2004

6.                  Pulmonary hypertension and pulmonary vascular remodeling in the newborn infant. Vascular Biology and Hypertension Program Seminar. UAB, Birmingham, AL. January 7, 2005

7.                  Prediction of outcomes in critically ill children. Child Health Investigative Forum (CHIF). UAB, Birmingham, AL. August 19, 2005

8.                  Probiotics in premature infants. Alabama Neonatology Network Conference. UAB, Birmingham, AL. September 1, 2005

9.                  Inhaled Nitric Oxide in premature infants. Alabama Neonatology Network Conference. UAB, Birmingham, AL. September 1, 2005.

10.              Moderator for 30th Annual Southeastern Conference on Perinatal Research, February 6-8, 2006

11.              Predicting outcome of infants diagnosed with hypoxemic-ischemic encephalopathy. Alabama Neonatology Network Conference. UAB, Birmingham, AL. April 27, 2006.

12.              Effects of hypoxia on the newborn lung. Alabama Neonatology Network Conference. UAB, Birmingham, AL. November 2, 2006.

13.              Vitamin A in preterm infants – from bedside to bench. Child Health Investigative Forum (CHIF). UAB, Birmingham, AL. November 3, 2006

 

 

MISCELLANEOUS:

 

Mentorship

Pre-doctoral candidates:

1.      Outside Research Director for Waldemar F. Carlo’s thesis research project, Harvard University Biology Undergraduate Programs, 1999-2000 (abst. 22; publ. 7, 9). Project title: Effects of cigarette smoke extract on neonatal pulmonary artery smooth muscle cells. Current position: Pediatric residency, Cincinnati, OH

2.      Research mentor for Linda Oniah, Ronald E. McNair Post-Baccalaureate Achievement Program, June –August 2001 (abst. 41). Project title: Development of a chicken embryo model to simulate the effects of maternal diabetes. Current position: Dental School

3.      Research mentor for Masheika James, Ronald E. McNair Post-Baccalaureate Achievement Program, June –August 2003 (abst. 38, 60). Project title: Retinoids and apoptosis in hyperoxic lung injury. Current position: Master’s program, UAB

Post-doctoral candidates:

1.      Clinical Research Mentor for Bridget A. Cobb, Fellow in Neonatology 2000-2003. Project title: Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infants. (Publication 14 in “Pediatrics”; abst 40, 43). Current position: Neonatologist in private practice, Atlanta, GA

2.      Clinical Research Mentor for Jorge Fabres, Fellow in Neonatology 2002-2005. Current position: Academic Neonatologist, Santiago, Chile (Publication 27 in “Pediatrics”; abst. 61).

3.      Basic Research Mentor for George El-Ferzli, Fellow in Neonatology 2002-2005. Current position: Research Fellow in Neonatology, UAB (abst. 62; PHA grant 2005-2006; manuscripts in preparation).

 

Internet-related work

4.      Author of the chapter on “Neonatal Fluids, Electrolytes, and Nutrition” at www.emedicine.com/PED/topic2554.htm

5.      Collection of neonatology teaching files at personal website

http://home.sprynet.com/~ambal/neonatal.htm

6.      Carlo WA, Ambalavanan N: Conventional Mechanical Ventilation: Traditional and New Strategies. Pediatr Rev (Online) 20(12):e117-e126, Dec 1999 http://pedsinreview.aapjournals.org/cgi/content/full/20/12/e117

7.      Collection of grant-related information at website: http://www.dpo.uab.edu/~ambal/grants.htm

 

REFEREE / REVIEWER FOR JOURNALS (in alphabetical order)

1.      Artificial Intelligence in Medicine (AIIM)

2.      American Journal of Obstetrics and Gynecology

3.      American Journal of Perinatology

4.      American Journal of Respiratory and Critical Care Medicine (AJRCCM; the Blue journal)

5.      Archives of Pediatrics and Adolescent Medicine

6.      Biology of the neonate (now “Neonatology”)

7.      BMC Pediatrics

8.      Indian Pediatrics

9.      Journal of Pediatrics

10.  Journal of the American Medical Association (JAMA)

11.  Maternal and Child Health Journal

12.  Pediatric Drugs

13.  Pediatrics

14.  Pediatrics International

15.  The American Journal of Clinical Nutrition

 

SOFTWARE

ANNE (Automated NeoNatal Entries) database software developed for PGIMER, Chandigarh (Sept 1993) in dBase IV programming language: Forms based user-friendly database for storing, analyzing neonatal patient data, and printing patient discharge summaries.