CURRICULUM VITAE
Date:
January 15, 2010
PERSONAL
INFORMATION
Name: NAMASIVAYAM AMBALAVANAN
RANK/TITLE Associate Professor
(Tenured), Department of Pediatrics
Department: Pediatrics;
Division of Neonatology
Secondary Appointments: Cell Biology; Molecular and Cellular
Pathology
Business
address: 525 New
Hillman Building
619 South 19th St., Birmingham, AL 35233 USA
Phone: 205-934-4680
Fax: 205-934-3100
Email: ambalATsprynet.com
HOSPITAL AND OTHER (NON-ACADEMIC
APPOINTMENTS):
1. Medical Staff, University of Alabama at Birmingham School of Medicine
2. Medical Staff, The
Children’s Hospital of Alabama
3. Pediatrician /
Neonatologist, Jefferson Clinic P.C., Birmingham
PROFESSIONAL
CONSULTANTSHIPS: None
EDUCATION:
Institution Degree Year
1. Medical School
Jawaharlal
Institute of PostGraduate Medical Education and Research (JIPMER)
Pondicherry, India MBBS 1988
2.
JIPMER
Pondicherry, India Internship 1990
3. Post Graduate Institute of Medical Education and Research (PGIMER)
Chandigarh, India MD
(Pediatrics) 1993
4. University of Alabama at Birmingham
Birmingham, Alabama,
USA 1 yr Pediatric
Residency 1996
3 yrs Neonatology Fellowship 1997
LICENSURE:
Licensed in the state of Alabama
Licensed
to practice medicine in India -permanent license
CERTIFICATION
Certified
in Pediatrics by American Board of Pediatrics
Certified
in Neonatal-Perinatal Medicine by American Board of Pediatrics
Awarded MD (Pediatrics) by PGIMER, India
(Silver Medalist; First in class): May 1993
POSTDOCTORAL TRAINING: See
Education
1. Post Graduate Institute of Medical Education and Research
Chandigarh, India MD
(Pediatrics) 1993
2. University of Alabama at Birmingham
Birmingham, Alabama, USA 1 yr Pediatric
Residency 1996
3 yr Neonatology Fellowship 1997
ACADEMIC APPOINTMENTS:
1. Associate
Professor with Tenure, Department of Pediatrics, Division of Neonatology, University
of Alabama at Birmingham (UAB): Oct 1, 2007 – present
2. Secondary
appointments in Department of Cell Biology, and Department of Molecular and
Cellular Pathology
3. Fellowship
Program Director, Division of Neonatology, University
of Alabama at Birmingham (UAB):
2009-present
4. Director,
Division of Neonatal Research, University
of Alabama at Birmingham (UAB):
2009-present
5. Co-Director,
Division of Neonatology, University
of Alabama at Birmingham (UAB): Nov
2008-present
6. Associate
Director, Division of Neonatology, University
of Alabama at Birmingham
(UAB): 2003 – 2008
7. Director,
Newborn Care Unit, Cooper Green
Hospital: Oct 2001-present
8. Director,
TReNDD (Translational Research in Normal
and Disordered Development) Program, UAB, 2009-present
9. Co-Director,
TReNDD (Translational Research in Normal and Disordered Development) Program, UAB,
2007 - 2009
10. Assistant
Professor, Department of Pediatrics, Division of Neonatology, University
of Alabama at Birmingham
(UAB): Oct 1, 2000 – Sept 30, 2007
11. Member,
Center for Free Radical Biology, UAB, 2007-present
12. Clinical
Assistant Professor, Department of Pediatrics, Division of Neonatology, UAB: May 1, 1998 – Sept 30, 2000 (unpaid academic appointment during
period of service in medically underserved county hospital)
13. Instructor,
Department of Pediatrics, Division of Neonatology, UAB: Feb 1, 1998 to Apr 30, 1998
14. Fellow/Instructor
in the Division of Neonatology, UAB: Oct
8, 1993 to Nov 7, 1997
AWARDS/HONORS
1. President, Southern Society
for Pediatric Research, 2005-6
2. Young Investigator Award (Basic Science; Southern Society for Pediatric
Research), 2000
3. Grant Reviewer (Ad hoc);
NICHD/NIH, 2004
4. Grant Reviewer (Cardiac
Biology/Regulation); American Heart Association, 2008->present
5. Grant Reviewer (Ad hoc):
American Association for the Advancement of Science (AAAS) Research
Competitiveness Program, 2007; Raine Medical Research Foundation, 2005; PSI Foundation, Canada, 2003; Yale CreFF, 2002
6. Chairman’s Award (Dept of
Pediatrics, University of Alabama at Birmingham), May 1997
7. Best Doctors in America, 2005-present
8. Ross Award in Research
(Southern Society of Pediatric Research), February 1997 and 1998
9. Highest scores in USA in the general pediatrics
certifying examination (770; Oct 1996) and in the neonatal-perinatal medicine
certifying examination (800; Nov 1997)
10. Medical School: Endowment prizes (first in
class) in Medicine, Pediatrics, Cardiology, and Radiology; Certificates of
Honor in Biochemistry, Medicine, Pediatrics, Surgery, and Cardiology
11. Entrance to residency programs in India: Ranked first in the All India Entrance Examination
(MCI), 1990 (Total candidates approx.
17,300); Ranked first in the JIPMER PG Entrance Examination, 1990 (Total
candidates approx. 800)
PROFESSIONAL SOCIETIES AND
MEMBERSHIPS
Society
for Pediatric Research (SPR)
Southern
Society for Pediatric Research (SSPR)
American
Thoracic Society (ATS)
American Academy of Pediatrics (AAP)
The
American Physiological Society (APS)
Jefferson County Medical Society (JCMS)
Medical Association of the State of Alabama
(MASA)
COUNCILS AND COMMITTEES
Medical
Executive and Credentials Committee, Jefferson Clinic P.C./Cooper Green Hospital
Council
Member, Southern Society for Pediatric Research, 2002-2004
President,
Southern Society for Pediatric Research, 2005-2006
UNIVERSITY ACTIVITIES
Fellowship
Program Director, Division of Neonatology
Director, TReNDD (Translational Research in Normal and
Disordered Development) Program, UAB
Co-Director,
Division of Neonatology
Chair,
Fellowship Oversight Committee, Division of Neonatology (2006-2008)
Member, UAB Medical Scientist Training Program (MSTP
Program, PhD Mentor)
Organizer,
Perinatal Health and Human Development (PHHD) Grant Program, Division of
Neonatology
Organizer,
Child Health Investigative Forum (CHIF)
Member,
Fellowship Recruitment Committee, Division of Neonatology
Member,
Perinatal Mortality Committee, Division of Neonatology (2004-2008)
PIN Replacement Committee (Physician Workflow Committee and Physician
Advisory Committee), UAB
Editorial Board Memberships
None
MAJOR RESEARCH INTERESTS
Basic research: Mechanisms underlying neonatal pulmonary vascular remodeling and neonatal pulmonary hypertension, in association with Dr. Yiu-Fai Chen and Dr. Suzanne Oparil of the Hypertension and Vascular Biology program at UAB, and Dr. Joanne Murphy-Ullrich of the Department of Pathology. Director of the TReNDD (Translational Research in Normal and Disordered Development) program: The TReNDD program is an interdisciplinary program of research and education, focused on disorders that affect the development and maturation of tissues and organ systems in late gestation and infancy (existing developmental biology programs primarily focus on embryologic development, and not late gestation and infancy, which is of more importance to pediatricians, especially neonatologists). The goal of this program includes the support of collaboration through state-of-the-art seminars, access to critical core facilities, and administrative support for multi-investigator projects, and to promote excellence in training and education of basic and clinical investigators.
Clinical research: Neonatal nutrition (specifically vitamin A), feeding practices, and
probiotics. In collaboration with Dr. Waldemar Carlo, director of the neonatal
division at UAB and Dr. Catharine Ross of Penn State University. Active in multiple projects in the NICHD Neonatal
Research Network.
Epidemiological research: prediction of neonatal outcomes, in association with Dr.
Waldemar Carlo and the Research Triangle Institute (RTI)/NICHD Neonatal
Research Network.
TEACHING EXPERIENCE
Experienced
in teaching pediatrics and neonatology to medical students, residents, and
fellows during my years of residency, fellowship, and post-fellowship academic
work.
Resident
evaluations in recent years (2004 onwards) have ranged from ~ 4.7-4.8 (of 5).
Teaching
includes:
1) monthly lectures to
pediatric residents and medical students,
2) Perinatal grand rounds twice
per year,
3) Pediatric grand rounds once
every two years,
4) Pediatric noon conference for pediatric
residents once every two years
5) Child Health Investigative
Forums (CHIF) once or twice every year
6) Annual pediatric board
review (neonatology topics) is also conducted once per year for PL-3 residents.
7) Organizer, Basic Research
Methods course for Physiology Seminars, for fellows-in-training in Department
of Pediatrics
8) PAT 702: Hughes Med-to-Grad
course on Phenotyping Human Disease (PhD students)
9) Fundamentals I small groups
(Medical Students)
Mentor
for students in Master’s degree and Undergraduate Biology programs at UAB since
2000;
Mentor for Neonatology fellows
since 2002; Mentor for PhD students since 2006
(see Mentorship section on page 21)
Other
education-related activities:
1. Collection of neonatology
teaching files and teaching images at division website (password required):
www.pedsportal.uab.edu/neonatology.htm
2. Collection of neonatology
teaching files at personal website
http://home.sprynet.com/~ambal/neonatal.htm
3. Collection of grant-related
information at website: http://www.dpo.uab.edu/~ambal/grants.htm
MAJOR LECTURES AND VISITING PROFESSORSHIPS: See invited lectures on page
22
GRANT SUPPORT:
Past
1) Ambalavanan (PI) 7/1/1995-06/30/1996
Wyeth Pediatrics Neonatology
Research Fund. $ 3,400
Research proposal: “Peptide
growth factors in neonatal pulmonary vascular remodeling”
2) Ambalavanan (PI) 12/1/2001-10/31/2003
CHRC (Child Health Research Center) $ 50,000 Annual 50%
effort
“Effects of endothelin-A
receptor blockade on hypoxic pulmonary vascular remodeling”
Mentor: YF Chen Ph.D.
3) Ambalavanan
(PI) 4/1/2003-3/31/2004
Cell Adhesion and Matrix
Research Center,
UAB $25,000 Annual 25% effort
4) PHA #0526041H (Ferzli) 07/01/2005-06/30/2006 0% effort
Pulmonary Hypertension
Association Annual funding $34,000
“Lung Assist Device in
Neonatal Porcine Respiratory Failure: Effect on Pulmonary Histopathology and
Lung Mechanics”
Role: Mentor/Sponsor
The
major goals of this project were to test the feasibility and efficacy of
reduction of lung injury using a novel lung assist device in neonatal porcine
respiratory failure
5) UAB PHHD PG (Ambalavanan) 08/01/2005 – 07/31/2006 0%
effort
UAB Perinatal Health and
Human Development Pilot Grant Annual funding $25,000
“TGF-beta in Lung Development
During Hypoxia”
Role: PI
The major goals of this project are to
determine the mechanisms by which TGF-b alters alveolar
development and vascular remodeling during hypoxia in the newborn lung
6) Ambalavanan (PI) 01/01/2006 – 12/31/2007 1%
effort
Children’s Center for
Research and Innovation Annual
funding $50,000
“Transforming Growth Factor b (TGF-b) and Neonatal Lung Development in Hypoxia”
Role: PI
To major goals of this
project are to test the hypotheses that hypoxia increases TSP-1, decreases
Thy-1, and thereby activates TGF-b which inhibits
MMP-2, leading to inhibition of alveolar development and abnormal pulmonary
arterial remodeling
“C-Reactive Protein in Extremely Low
Birth Weight Neonates”
Role: PI
NIH Annual Direct Costs: $250,000
“Transforming
Growth Factor -Beta Mediates Effects of Hypoxia in Newborn Lung”
Role:
PI
Major
Goal: To determine the mechanisms by which hypoxic exposure during lung
development activates TGF-β resulting in abnormal pulmonary arterial
remodeling (PAR) and inhibition of alveolar development (IAD). Specific Aim 1
will test the hypothesis that TGF-β signaling is necessary for
hypoxia-induced PAR and IAD. Specific Aim 2 will assess the mechanistic role of
Thy-1 in TGF-β activation and the pathogenesis of IAD in the presence or
absence of hypoxia. Specific Aim 3 will test the specific hypothesis that
hypoxia-induced increases in ET-1 stimulate TGF-β synthesis and activation
2) 2 U01 HD34216 (Carlo) 04/01/96 – 03/31/11 3% effort
NICHD $822,388
Role: Co-investigator
(Alternate PI)
The
major goals of this project are to work with the NICHD and the Steering
Committee to prioritize, plan, implement, analyze, interpret, and report a
series of randomized and observational studies.
Current
projects:
Co-PI
of Probiotics in Preterm Infants trial, PI of probiotic pilot studies; Premie
iNO ancillary study; Cytokine ancillary study;
3)
R01 HD059140 (PI: Ardythe Morrow)
12/01/2008-11/30/2013 5% effort (0.6
calendar months)
“Novel genetic and salivary glycan biomarkers
for risk of NEC in ELBW infants”
Role:
Co-Investigator
The
Specific Aims of this project are to: 1) Test FUT2 genotype and salivay H-2 and sLea phenotypes as
novel biomarkers of subsequent risk of NEC; 2) Examine the pattern of
intestinal bacterial colonization in ELBW infants in relation to their glycan
genotype and phenotype, antibiotic treatment history, and NEC outcome; and 3)
Determine the predictive value of multivariate models that include multiple
putative biomarkers for risk of NEC, including gene polymorphisms, salivary
glycans, and measures of early inflammation.
4)
NA09OAR4170199
(PI: Sadis Matalon) 8/1/09
– 7/31/10 2.5% effort (0.3 calendar months)
“Nanoparticle induced injury to adult and developing lungs”
NOAA
Role: Project leader, Project 4
The
objective of this project is to determine if exposure of newborn and fetal mice
to nanoparticles impairs lung development and leads to injury.
1) AHA 0855012E (Ambalavanan) 07/01/2008 - 6/30/2010 10%
effort
American Heart Association Greater South East
Affiliate
Annual Direct Cost: $75,000
“Transforming Growth Factor-
Beta Mediates Effects of Hypoxia in Newborn Lung”
Role: PI
[This application was alternative to NIH R01 HL092906]
The
objective of this project is to determine the mechanisms by which hypoxia
during lung development activates TGF-β resulting in PAR and IAD. Specific
Aim 1 will test the hypothesis that TGF-β signaling is necessary for
hypoxia-induced PAR and IAD. Specific Aim 2 will assess the mechanistic role of
Thy-1 in TGF-β activation and the pathogenesis of IAD in the presence or
absence of hypoxia
BIBLIOGRAPHY:
(62 Medline-indexed
publications as of December 10, 2009 + 1 in press)
MANUSCRIPTS:
Peer-reviewed publications:
(In
chronological order with earliest first):
1. Trehan A, Singh S, Ambalavanan
N, Kumar L. Valvular Heart Disease: Rheumatic or Rheumatoid?. Indian Pediatr 34: 641- 644, 1997
2. Rayyis SF, Ambalavanan N,
Wright L, Carlo WA. Randomized trial of "Slow" vs. "Fast"
feed advancements on the incidence of necrotizing enterocolitis in very low
birth weight infants. J Pediatr 134:293-297, 1999
3. Ambalavanan N, Bulger A, Philips JB III.
Hypoxia-induced release of peptide growth factors from neonatal porcine
pulmonary artery smooth muscle cells. Biol Neonate 76:311-319, 1999
4. Ambalavanan N, Mariani G, Bulger A,
Philips JB III. Role of nitric oxide in regulating neonatal porcine pulmonary
artery smooth muscle cell proliferation.
Biol Neonate 76:291-300, 1999
5. Ambalavanan N, Nelson K, Alexander G,
Johnson SE, Biasini F, Carlo WA. Prediction of neurologic morbidity in
extremely low birth weight infants. J Perinatol 20: 496-503, 2000
6. Ambalavanan N, Carlo WF, Bulger A, Shi J,
Philips JB III. Effect of cigarette smoke extract on neonatal porcine vascular
smooth muscle cells. Tox Appl Pharmacol 170: 130-136, 2001
7. Ambalavanan N, Bulger A, Ware J, Philips
JB III. Hemodynamic effects of levcromakalim in neonatal porcine pulmonary
hypertension. Biol Neonate 80: 74-80, 2001
8. Carlo WF, Villamor E, Ambalavanan N, DeMey JG, Blanco CE. Chronic exposure to
cigarette smoke extract impairs endothelium-dependent relaxation of chicken
embryo pulmonary arteries. Biol Neonate 80:247-250, 2001
9. Ambalavanan N, Carlo WA. Comparison of the prediction of
extremely low birth weight neonatal mortality by regression analysis and by
neural networks. Early Hum Dev 65:123-137, 2001
10. Ambalavanan
N, Bulger A, Ware J, St. John E, Philips JB III. Feasibility
of nitric oxide administration by oxygen hood in a neonatal pulmonary
hypertension. J Perinatol 22:50-56, 2002
11. Ambalavanan
N, Philips JB 3rd, Bulger A, Oparil S, Chen YF. Endothelin-A
receptor blockade in porcine pulmonary hypertension. Pediatr
Res 52:913-921, 2002
12. Ambalavanan N, Novak ZE. Peptide growth
factors in tracheal aspirates of mechanically ventilated preterm neonates.
Pediatr Res 53:240-244, 2003
13. Ambalavanan N, Wu TJ, Tyson JE, Kennedy
KA, Roane C, Carlo WA. A comparison of three vitamin A dosing regimens in
extremely premature infants. J Pediatr 142:656-61, 2003
14. Cobb BA, Carlo WA, Ambalavanan N*. Gastric residuals and their relationship
to necrotizing enterocolitis in very low birth weight infants. Pediatrics
113:50-53, 2004 [*Mentor of Dr. Cobb; corresponding author]
15. Castro L, Yolton K, Haberman
B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan
EF. Bias in reported neurodevelopmental
outcomes among extremely low birth weight survivors. Pediatrics 114: 404-410,
2004
16. Ambalavanan N,
Kennedy K, Tyson J, Carlo WA. Survey of vitamin A supplementation for extremely
low birth weight (ELBW) infants: Is clinical practice consistent with the
evidence? J Pediatr 145:304-307, 2004
17. Ambalavanan N,
Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. Endothelin-A receptor blockade
prevents and partially reverses neonatal hypoxic pulmonary vascular remodeling.
Pediatr Res 57:631-636, 2005
18. Ambalavanan N,
Tyson JE, Kennedy KA, Hansen N, Vohr BR, Wright LL, Carlo WA, and the NICHD
Neonatal Research Network. Vitamin A supplementation for extremely low birth
Weight infants: Outcome at 18-22 months. Pediatrics 115:e249-54, 2005
19. Ambalavanan N, Ross AC, Carlo WA. Retinol-binding protein, transthyretin, and c-reactive
protein in extremely low birth weight (ELBW) infants. J Perinatol 25:714-9,
2005
20. Ambalavanan N,
Carlo W, Bobashev G, Mathias E, Poole K, Fanaroff AA, Stoll BJ, Ehrenkranz R,
Wright LL. Prediction of mortality for extremely low birth weight neonates.
Pediatrics 116:1367-73, 2005
21. Chen YF, Feng JA, Li P, Xing D, Serra R, Ambalavanan
N, Majid-Hassan E, Oparil S. Dominant
negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary
vascular remodeling. J Appl
Physiol 100:564-71, 2006
22. Ambalavanan N, Baibergenova A, Carlo WA,
Saigal S, Schmidt B, Thorpe KE, and the TIPP Investigators. Early prediction of
poor outcome in extremely low birth weight (ELBW) infants by classification
tree analysis. J Pediatr 148:438-44, 2006
23. Chen YF, Feng JA, Li P, Xing
D, Ambalavanan N, Oparil S. Atrial natriuretic peptide-dependent
modulation of hypoxia-induced pulmonary vascular remodeling Life Sci. 79:1357-65, 2006
24. Ross AC, Ambalavanan
N, Zolfaghari R, Li NQ. Vitamin A
combined with retinoic acid increases retinol uptake and lung retinyl ester
formation in a synergistic manner in neonatal rats. J Lipid Res. 47:1844-51,
2006
25. Ambalavanan N,
Carlo WA, Shankaran S, Bann CM, Emrich SL, Higgins RD, Tyson JE, O’Shea TM,
Laptook AR, Ehrenkranz RA, Donovan EF, Walsh MC, Goldberg RN, Das A, and
Follow-up Investigators for the NICHD Neonatal Research Network. Predicting
outcome of neonates diagnosed with hypoxemic-ischemic encephalopathy.
Pediatrics 118: 2084-93, 2006
26. Ross AC, Ambalavanan N. Dexamethasone does not antagonize the increase in retinyl
esters in the lungs of neonatal rats treated with vitamin A combined with
retinoic acid (VARA). Neonatology 92:26-32, 2007
27. Fabres J, Carlo WA, Phillips V, Howard G, Ambalavanan
N*. Both extremes of arterial
carbon dioxide pressure and the magnitude of fluctuations in arterial carbon
dioxide pressure are associated with severe intraventricular hemorrhage in
preterm infants. Pediatrics 119:299-305,
2007 [*Mentor of Dr.
Fabres; corresponding author]
28. Ambalavanan N, Li
P, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. Endothelin –1 mediates hypoxia-induced increases in vascular collagen in
the newborn mouse lung. Pediatr Res 61:559-564, 2007
29. Broitman E, Ambalavanan N*, Higgins RD, Vohr
BR, Das A, Bhaskar B, Murray K, Hintz SR, Carlo WA; National Institute of Child
Health and Human Development Neonatal Research Network. Clinical data predict
neurodevelopmental outcome better than head ultrasound in extremely low birth
weight infants. J Pediatr. 151:500-505, 2007 [*Mentor of Dr.
Broitman; corresponding author]
30. Ambalavanan N,
Nicola T, Li P, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. Role of matrix
metalloproteinase-2 in newborn mouse lungs under hypoxic conditions. Pediatr
Res 63:26-32, 2008
31. Ambalavanan N,
Van Meurs KP, Perritt P, Carlo WA, Ehrenkranz RA, Stevenson D, Lemons JA, Poole
WK, Higgins RD, for the NICHD Neonatal Research Network. Predictors of death or
bronchopulmonary dysplasia in preterm infants with respiratory failure. J
Perinatol 28:420-426, 2008
32. Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD
Research Network. Neurodevelopmental outcome of extremely low birth weight
infants with posthemorrhagic hydrocephalus requiring shunt insertion.
Pediatrics 121:e1167-1177, 2008 [listed as collaborator]
33. Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH,
Ambalavanan N,
Malkus H, Homer RJ, Elias JA. Developmental regulation of NO-mediated
VEGF-induced effects in the lung. Am J Resp Cell Mol Biol 39:420-430, 2008
34. Ambalavanan N, Nicola T, Hagood
J, Bulger A, Serra R, Murphy-Ullrich J, Oparil S, Chen YF. Transforming growth factor-beta signaling mediates
hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar
development in newborn mouse lung. Am J Physiol Lung Cell Mol Physiol 295:L86-L95, 2008.
35. Isbell TS, Sun C-W, Wu L-C, Teng X, Vitturi DA, Branch
BG, Kevil CG, Peng N, Wyss JM, Ambalavanan N,
Schwiebert L, Ren J, Pawlik KM, Renfrow MB, Patel RP, Townes TM. SNO-Hemoglobin
not essential for red blood cell dependent hypoxic vasodilation. Nat Med 14: 773-777, 2008
36. Bruckner TA, Carlo WA, Ambalavanan N,
Gould JB. Neonatal mortality among low birth weight infants during the initial
months of the academic year. J Perinatol. 28:691-695, 2008
37. Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ;
Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight
preterm infants with surgical short bowel syndrome: incidence, morbidity and
mortality, and growth outcomes at 18 to 22 months. Pediatrics 122:e573-e582,
2008 [listed as collaborator]
38. Soltau TD, Carlo
WA, Gee J, Gould J, Ambalavanan N*. Mortality and morbidity by month of birth of neonates
admitted to an academic neonatal intensive care unit. Pediatrics 122:e1048-e1052,
2008 [*Mentor of Dr.
Soltau; corresponding author]
39. Cotten MC, Taylor S, Stoll BJ, Goldberg RN, Hansen N,
Sanchez P, Ambalavanan N,
Benjamin DK Jr. Prolonged duration of initial empirical antibiotics is
associated with increased necrotizing enterocolitis and mortality in extremely
low birth weight infants. Pediatrics 123:58-66, 2009
40. Ambalavanan N,
El-Ferzli GT, Roane C, Johnson R, Carlo WA. Nitric oxide administration using
an oxygen hood: A pilot trial. PLoS One 4(2):e4312, 2009
41. Askenazi DJ, Griffin R, McGwin G, Carlo W, Ambalavanan
N. Acute kidney injury is independently associated with mortality in very
low birthweight infants: a matched case-control analysis. Pediatr Nephrol. 24
:991-7, 2009
42. Nicola T, Hagood JS, James ML, Macewen MW, Williams
TA, Hewitt MM, Schwiebert LM, Bulger A, Oparil S, Chen YF, Ambalavanan N*.
Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am J
Physiol Lung Cell Mol Physiol. 296:L738-50, 2009 [*Mentor of Dr.
Nicola; corresponding author]
43. Ambalavanan N,
Carlo WA, D’Angio CT, McDonald SA, Das A, Schendel D, Thorsen P, Higgins RD for
the NICHD Neonatal Research Network. Cytokines associated with bronchopulmonary dysplasia or death in
extremely low birth weight infants. Pediatrics 123:1132-41, 2009
44. Dasgupta C, Sakurai R, Wang Y, Guo P, Ambalavanan N,
Torday JS, Rehan VK. Hyperoxia-induced neonatal rat lung injury involves
activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone.
Am J Physiol Lung Cell Mol Physiol. 296:L1031-41, 2009
45. Vohr BR, Tyson JE, Wright LL, Perritt RL, Li L, Poole
WK; NICHD Neonatal Research Network. Maternal age, multiple birth, and
extremely low birth weight infants. J Pediatr.154:498-503.e2, 2009. [listed as
collaborator]
46. McKee LA, Fabres J,
Howard G, Peralta-Carcelen M, Carlo WA, Ambalavanan N*. PaCO2 and neurodevelopment in
extremely low birthweight infants. J Pediatr 155:217-21.e1, 2009 [*Mentor of Dr. McKee and Dr. Fabres; corresponding author]
47. El-Ferzli GT, Philips JB III, Bulger A, Ambalavanan
N. A pumpless lung assist device reduces mechanical ventilation-induced
lung injury in juvenile piglets. Pediatr Res 66: 671-676, 2009 [*Mentor of Dr. Ferzli]
48. El-Ferzli GT, Philips JB III, Bulger A, Ambalavanan
N. Evaluation of a pumpless lung assist device in hypoxia-induced pulmonary
hypertension in juvenile piglets. Pediatr Res 66: 677-681, 2009 [*Mentor of Dr. Ferzli]
49. Laptook AR, Shankaran S, Ambalavanan N, Carlo WA,
McDonald SA, Higgins RD, Das A, Hypothermia Subcommittee of the NICHD Neonatal
Research Network. Outcome of term infants using apgar scores at 10 minutes
following hypoxic-ischemic encephalopathy. Pediatrics 124:1619-1626, 2009.
50. Hintz SR, Bann CM, Ambalavanan
N, Cotten MC, Das A, Higgins RD for the Eunice Kennedy Shriver NICHD
Neonatal Research Network. Predicting time to hospital discharge for extremely
preterm infants. Pediatrics 125:e146-e154, 2010.
Manuscripts in press:
Manuscripts submitted but not yet accepted:
1.
James ML, Ross
AC, Bulger A, Philips JB III, Ambalavanan
N*. Vitamin
A and retinoic acid act synergistically to reduce hyperoxic lung injury in
newborn mice. [*Mentor of Ms.
James; corresponding author]
2.
Bell EF, Hansen
NI, Morriss FH, Stoll BJ, Ambalavanan N, Gould JB, Laptook AR, Walsh MC,
Carlo WA, Shankaran S, Das A, Higgins RD, for the NICHD Neonatal Research
Network. Impact of timing of birth and resident duty-hour restrictions on
neonatal mortality and morbidity in very low birth weight infants.
3.
Ambalavanan N, Carlo WA, McDonald SA, Das A, Schendel DE, Thorsen
P, Hougaard DM, Skogstrand K, Higgins RD for the Cytokine and GDB Subcommittees
of the Eunice Kennedy Shriver NICHD Neonatal Research Network. Cytokines
associated with post-hemorrhagic ventricular dilation in extremely low birth
weight infants.
4.
Ambalavanan N, Walsh M, Bobashev G, Das A, Levine B, Carlo WA,
Higgins RD, for the Eunice Kennedy Shriver NICHD Neonatal Research Network.
Origins of Inter-center differences – why do rates of bronchopulmonary
dysplasia or death in very low birth weight infants vary among centers?
Non peer-reviewed
publications
(Medline-indexed in bold)
1. Ambalavanan N, Carlo WA. Current
approaches to mechanical ventilation. Tufts University School of Medicine and Floating
Hospital for Children Reports on: Neonatal Respiratory Diseases. Volume 8, No.
2, 1998 [review]
2.
Ambalavanan N, Carlo WA. How would you handle these newborns? Contemporary
Pediatrics 16(6): 115-133, 1999
3. Carlo WA, Ambalavanan N. Conventional Mechanical Ventilation:
Traditional and New Strategies. Pediatr Rev 20(12):e117-e126, 1999 [review]
4. Ambalavanan
N, Carlo WA. Analgesia for ventilated neonates: Where do we stand? J
Pediatr 135:403-405, 1999 [editorial]
5. Ambalavanan
N, Carlo WA. Hypocapnia and hypercapnia in respiratory management of
newborn infants. Clin Perinatol 28(3):517-531, 2001 [review]
6. Ambalavanan N.
Recent advances in fluid management. Journal of Neonatology 16 (1): 59-65, 2002 [review]
7. Ambalavanan N, Whyte R. The
mismatch between evidence and practice: common therapies in search of evidence.
Clin Perinatol 30:305-331, 2003 [review]
8. Ambalavanan N, Carlo WA.
Bronchopulmonary dysplasia: new insights. Clin Perinatol 31:613-628,
2004 [review]
9. Ambalavanan N, Toms R.
Permissive hypercapnia during mechanical ventilation of neonates. Indian Pediatrics
41:775-778, 2004. [editorial]
10. Carlo WA, Prince LS, St John EB, Ambalavanan N.
Care of very low birth weight infants with respiratory distress syndrome: an
evidence-based review. Minerva Pediatr. 56:373-80, 2004 [review]
11. Ambalavanan N.
Surfactant therapy. Indian Journal of Practical Pediatrics 7(3):192-200, 2005
[review]
12. Shuford-Hopkins E, Bulger A, Ambalavanan N,
Philips JB 3rd. Doxycycline inhibits matrix metalloproteinase-2 (MMP-2)
production by neonatal pulmonary artery endothelial cells. Ethn Dis. 15(3 Suppl
4):S4-98-9, Summer 2005
13. Ambalavanan
N, Carlo WA. Ventilatory strategies in the prevention and management of bronchopulmonary
dysplasia. Semin Perinatol 30:192-9, 2006 [review]
14. Ambalavanan
N. Endothelin-A receptor blockade inhibits the effects of hypoxia on the
newborn lung vasculature. ScientificWorldJournal. 6:669-70, 2006 [review]
15. Ambalavanan
N, Carlo W. How can we prevent early death in preterm infants? J Pediatr
(Rio J). 84: 283-385, 2008
16. Thome UH,
Ambalavanan N. Permissive hypercapnia to decrease lung injury in ventilated
preterm infants. Semin Fetal Neonatal Med 2008 Oct 28 [Epub ahead of print]
[review]
17. Askenazi DJ,
Ambalavanan N, Goldstein SL. Acute kidney injury in critically ill
newborns: What do we know? What do we need to learn? Pediatr Nephrol 24:265-74,
2008 [review]
Other Publications:
BOOKS:
Books and Book Chapters
1. Ambalavanan N, Mariani G, Philips JB III:
Role of Peptide Growth Factors in Cardiovascular Development. In Polin RA, Fox WW (Eds): Fetal and
Neonatal Physiology, ed 2. WB Saunders Co, Philadelphia, PA, 1997, pp 814-826
2. Waldemar Carlo, Namasivayam Ambalavanan, Robert Chatburn: Section
IV: Mechanical Ventilation. Chapter 15: Basic Principles of Mechanical
Ventilation, Chapter 16: Classification of Mechanical Ventilation Devices,
Chapter 17: Ventilator Parameters. In
Sinha SK, Donn SM (Eds): Manual of Neonatal Respiratory
Care. Futura Publishing Company, Inc., Armonk, New York, USA, 2000
3. Waldemar A Carlo, Namasivayam Ambalavanan: Wentylacja Mechaniczna
(Mechanical ventilation [Polish] ). In
Gadzinowski J, Vidyasagar D (Eds): Neonatologia. Osrodek Wydawnictw Naukowych. Poznan, 2000, pp 287-301
4. Namasivayam Ambalavanan,
Waldemar Carlo: Meconium Aspiration Syndrome. In Burg FD, Ingelfinger JR,
Polin RA, Gershon AA (Eds): Gellis and Kagan’s Current Pediatric Therapy. WB
Saunders Co., Philadelphia, PA, 2002, pp 265-268
5. Namasivayam Ambalavanan, Schelonka RL, Carlo WA:
Ventilatory Strategies. In Goldsmith JP, Karotkin EH (Eds). Assisted
ventilation of the neonate. 4th Edition. WB Saunders Co, Philadelphia, PA, 2003, pp 249-259
6. Namasivayam Ambalavanan, Carlo WA: Vitamin A in the
prevention of bronchopulmonary dysplasia. In
Bronchopulmonary Dysplasia. Series: Lung Biology in Health and Disease. Volume
240. Steven Abman (Ed). Informa Healthcare USA, Inc., New York, NY, 2009, pp 446-457
7. Namasivayam Ambalavanan: “Neonatal Fluids,
Electrolytes, and Nutrition” on emedicine
at http://emedicine.medscape.com/article/976386-overview
8. Namasivayam Ambalavanan, Thomas Soltau: “Bronchopulmonary
Dysplasia” on emedicine at: http://emedicine.medscape.com/article/973717-overview
9. Namasivayam Ambalavanan, Carlo WA: Chapters on
Transient Tachypnea of Newborn, Meconium Aspiration Syndrome, Persistent
Pulmonary Hypertension of Newborn, Pulmonary Hemorrhage, Neonatal Jaundice and
Kernicterus, and Hypoxic-Ischemic Encephalopathy for new Edition of Nelson’s
Textbook of Pediatrics (in press)
Published abstracts:
(78 of 82 accepted
for presentation: all except 14, 23, 47, 48):
1. Ambalavanan N, Philips JB IV, Bulger A,
Philips JB III: The Effect of pH on Neonatal Pulmonary Artery Smooth Muscle and
Endothelial Cell Proliferation. J
Investig Med 43(1): 44A, Feb 1995
2. Ambalavanan N, Bryant L, Bulger A,
Philips JB III: Nitric oxide donors inhibit neonatal pulmonary artery smooth
muscle cell proliferation. Pediatr Res 37(4): 324 A, April 1995
3. Ambalavanan N, Bulger A, Philips JB III:
Hypoxia increases vascular endothelial growth factor production by neonatal
pulmonary artery smooth muscle cells. Pediatr Res 37(4): 324 A, April 1995
4. Ambalavanan N, Bulger A, Philips JB III:
The effect of pH on neonatal pulmonary artery smooth muscle and endothelial
cell proliferation. Pediatr Res 37(4):
325 A, April 1995
5. Ambalavanan N, Bulger A, Philips JB III:
Does a heme protein regulate hypoxia-mediated changes in neonatal pulmonary
artery smooth muscle cell proliferation?
J Investig Med 45(1): 67A, Jan 1997
6. Ambalavanan N, Bulger A, Philips JB III:
Hypoxia-mediated release of peptide growth factors from neonatal pulmonary
artery smooth muscle cells. J Investig
Med 45(1): 21A, Jan 1997
7. Ambalavanan N, Bulger A, Philips JB III:
Hypoxia-mediated release of peptide growth factors from neonatal pulmonary
artery smooth muscle cells. Pediatr Res
41(4): 245A, April 1997
8. Ambalavanan N, Bulger A, Philips JB III:
Does a heme protein regulate hypoxia-mediated changes in neonatal pulmonary
artery smooth muscle cell proliferation?
Pediatr Res 41(4): 244A, April 1997
9. Ambalavanan N, Bulger A, Philips JB III:
Regulation of neonatal pulmonary artery smooth muscle cell proliferation by
nitric oxide. Pediatr Res 41(4): 244A,
April 1997
10. Mariani G, Ambalavanan N,
Bulger A, Philips JB III: Prostaglandin E1 and peptide growth factors stimulate
neonatal pulmonary artery smooth muscle cell proliferation in a synergistic
manner. Pediatr Res 41(4): 260A, April
1997
11. Rayyis S, Ambalavanan N,
Wright L, Carlo WA: Randomized trial of “Slow” versus “Fast” feeding
advancement in very low birthweight infants. Pediatr Res 41(4): 172A, April 1997
12. Ambalavanan N, Bulger A, Philips JB III:
Hypoxia-inducible factor-1 (HIF-1) does not mediate hypoxic inhibition of
neonatal pulmonary artery smooth muscle cell proliferation. J Investig Med
46(1): 23A, Jan 1998
13. Ambalavanan N, Bulger A, Philips JB:
Hypoxia-mediated alterations of signal transduction pathways in neonatal
pulmonary artery smooth muscle cells. Pediatr
Res 43(4): 273A, April 1998
14. Ambalavanan N, Carlo WA: Prediction of
mortality in ELBW infants using logistic and linear regression versus neural
networks. Pediatr Res 43(4): 205A, April 1998
15. Ambalavanan N, Nelson K, Alexander G,
Carlo WA: Prediction of neurologic morbidity and its determinants in ELBW
infants. Pediatr Res 43(4): 205A, April 1998
16. Carlo WF, Ambalavanan N,
Bulger A, Philips JB III: The effect of cigarette smoke extract on neonatal
pulmonary artery smooth muscle cell proliferation. J Investig Med 47(2): 141A,
Feb 1999
17. Ambalavanan N, Carlo WF, Bulger A, Shi J,
Philips JB III: Cigarette smoke extract causes non-apoptotic cell death in
neonatal vascular smooth muscle cells. Pediatr Res 45(4):294A, Apr 1999
18. Ambalavanan N, Carlo WA: Prediction of
extremely low birth weight (ELBW) neonatal mortality by neural networks and
logistic regression. Pediatr Res: 236A, Apr 1999
19. Philips JB, Ambalavanan N,
Ware J, Bulger A, Lin B, Pritchard DG: Group B Streptococcal Hyaluronidase Does
Not Increase Systemic Bacterial Invasion in a Neonatal Rat Pup Model. Pediatr
Res 272A, Apr 1999
20. Ambalavanan N, Bulger A, Ware J, St.John
E, Philips JB III: Nitric oxide administration by oxygen hood in neonatal
pulmonary hypertension. J Investig Med 48(1): 134A, Jan 2000
21. Ambalavanan N, Bulger A, Ware J, Philips
JB III: ATP-gated potassium channels in neonatal pulmonary hypertension. J
Investig Med 48(1): 152A, Jan 2000
22. Carlo WF, Villamor EI, Ambalavanan
N, DeMey JG, Blanco C: Chronic exposure to cigarette smoke extract impairs
endothelium-dependent vasodilation of chick embryo pulmonary arteries. Pediatr
Res Pediatr Res 47(4): 353A, Apr 2000
23. Ambalavanan N, Bulger A, Ware J, Philips
JB III: ATP-gated potassium channels in neonatal pulmonary hypertension.
Pediatr Res 47(4): 350A, Apr 2000
24. Ambalavanan N, Bulger A, Ware J, St.John
E, Philips JB III: Nitric oxide administration by oxygen hood in neonatal
pulmonary hypertension. Pediatr Res 47(4): 350A, Apr 2000
25. Haberman B, Donovan E, Ambalavanan
N, Hansen N, Vohr B, and the NICHD Neonatal Research Network Follow-up
Subcommittee: Follow-up Compliance of Newborn Intensive Care Unit (NICU)
Survivors. Pediatr Res 47(4): 312A, Apr 2000
26. Ambalavanan N, A Bulger, TJ Wu, JB
Philips, III: Retinol induces apoptosis and release of basic FGF from neonatal
pulmonary endothelial and smooth muscle cells. J Investig Med 49(1): 129A, Jan
2001
27. Ambalavanan N, A Bulger, J Ware, YF Chen,
JB Philips, III: Endothelin –A receptor blockade in neonatal pulmonary
hypertension. J Investig Med 49(1): 129A, Jan 2001
28. Teng RJ, A Bulger, Ambalavanan
N, JB Philips III, JS Beckman: Nitrotyrosine affects growth and protein
expression of pulmonary artery endothelial cells. J Investig Med 49(1): 128A,
Jan 2001
29. Ambalavanan N, A Bulger, J Ware, YF Chen,
J B Philips, III: Endothelin-A receptor blockade in neonatal pulmonary
hypertension. Pediatr Res 49 (4):269A, Apr 2001
30. Ambalavanan N, A Bulger, TJ Wu, J B
Philips, III: Retinol induces apoptosis and release of peptide growth factors
from neonatal lung cells. Pediatr Res 49 (4):269A, Apr 2001
31. Panyavudhikrai S, A Bulger, N Ambalavanan, RJ Teng, JB Philips:
Effect of dexamethasone on endothelial nitric oxide synthase (eNOS) levels in
hypoxic pulmonary artery endothelial cells. Pediatr Res 49 (4):283 A, Apr 2001
32. Ambalavanan N, W A Carlo, J Roayaei, LL
Wright, AA Fanaroff, BJ Stoll, RA Ehrenkranz, K Poole: Prediction of mortality
in extremely low birth weight (ELBW) infants. Pediatr Res 49 (4):316A, Apr 2001
33. Ambalavanan N, Z Novak: Peptide growth
factors in tracheal aspirates of mechanically ventilated preterm neonates. J
Investig Med 50 (1): 130A, Jan 2002
34. Ambalavanan N, TJ Wu, JE Tyson, KA
Kennedy, C Roane, WA Carlo: A randomized controlled trial of three vitamin A
dosing regimens in extremely low birth weight infants. Pediatr Res 51(4): 339A,
Apr 2002
35. Panyavudhikrai S, A Bulger, N Ambalavanan, RJ Teng, JB Philips, III:
Effect of dexamethasone on endothelin-1 production by resistance pulmonary
artery endothelial cells during normoxia and hypoxia. Pediatr Res 51(4): 357A,
Apr 2002
36. Ambalavanan N, Z Novak:
Peptide Growth Factors In Tracheal Aspirates Of Mechanically Ventilated Preterm
Neonates. Am J Resp Crit Care Med 165(8): A646, Apr 2002
37. Ambalavanan N, A Bulger, YF
Chen, S Oparil, J Murphy-Ullrich, J Engler:
Endothelin-A receptor blockade in neonatal hypoxic pulmonary vascular
remodeling. J Investig Med 51:S291, Feb 2003
38. James ML, A
Bulger, JB Philips III, N Ambalavanan: Mechanisms of
apoptosis induced by retinoic acid in neonatal resistance pulmonary artery
smooth muscle cells. J Investig Med 51:S291, Feb 2003
39. Tanner J, A
Novak, N Ambalavanan: Matrix
metalloproteinase-2 (MMP-2) in relation to bronchopulmonary dysplasia. J
Investig Med 51:S292, Feb 2003
40. Cobb BA, WA
Carlo, N Ambalavanan: Feeding
intolerance and its relationship to necrotizing enterocolitis (NEC) in very low
birth weight infants. J Investig Med 51:S309-310, Feb 2003
41. Oniah LN, N Ambalavanan, A Bulger:
Development of a chicken embryo model to simulate effects of maternal diabetes.
J Investig Med 51:S310, Feb 2003
42. Ambalavanan N, K Kennedy, J
Tyson, WA Carlo: Vitamin A supplementation in extremely low birth weight (ELBW)
infants: prevalence and factors inhibiting its widespread use. Pediatr Res
53(4): 371A, April 2003
43. Cobb BA, WA
Carlo, N Ambalavanan: Feeding
intolerance and its relationship to necrotizing enterocolitis (NEC) in very low
birth weight (VLBW) infants. Pediatr Res 53(4): 383A, April 2003
44. Dimmitt RA, BA
Cobb, RL Schelonka, N Ambalavanan: Analysis of
risk factors for necrotizing enterocolitis. Pediatr Res 53(4): 383A, April 2003
45. Tanner JM, N Ambalavanan, RL Schelonka:
Combined immunodeficiency attenuates murine hyperoxic lung injury. Pediatr Res
53(4): 401A, April 2003
46. Tanner JM, N Ambalavanan: Matrix
metalloproteinase-2 (MMP-2) in relation to bronchopulmonary dysplasia. Pediatr
Res 53(4): 411A, April 2003
47. Broitman EA, D
Young, K Nelson, WA Carlo, N Ambalavanan: Prediction of poor neurologic
outcome in VLBW infants with Grade IV IVH. Pediatr Res 53(4): 470A, April 2003
48. Teng RJ, N Ambalavanan, TJ Wu, A
Bulger, JB Philips: Superoxide and NO are both required for
nitrotyrosine-mediated apoptosis of pulmonary artery endothelial cells. Pediatr
Res 53(4): 510A, April 2003
49. Ambalavanan N, A Bulger, J
Murphy-Ullrich, J Engler, YF Chen, S Oparil: Endothelin-A
receptor blockade prevents and reverses neonatal hypoxic pulmonary vascular
remodeling. Pediatr Res 53(4): 431A, April 2003
50. Ambalavanan N, A Bulger, J
Windsor, J Engler, J Murphy-Ullrich, YF Chen, S Oparil: Hypoxia
increases matrix metalloproteinase-2 in the neonatal pulmonary vasculature.
Pediatr Res 53(4): 431A, April 2003
51. Ambalavanan N, AC Ross, WA Carlo. Transthyretin and the
Retinol Binding Protein / Transthyretin Molar Ratio in Extremely Low Birth
Weight (ELBW) Infants. Pediatr Res 55(4): 443A, April 2004
52. Broitman E, N Ambalavanan, R Higgins, A Das, B Bhaskar,
K Murray, B Vohr, S Shankaran, S Hintz, W Carlo. Cranial Ultrasound Closer to 36 Weeks but Not in the First 28 Days When
Combined with Clinical Variables Is Predictive of Long-Term Neurodevelopmental
Outcome. Pediatr Res 55(4): 370A, April 2004
53. Ambalavanan
N, A Baibergenova, WA, Carlo, S Saigal, B Schmidt, KE Thorpe, the TIPP
Investigators. Early Prediction of Poor
Outcome in Extremely Low Birth Weight (ELBW) Infants by Classification and
Regression Tree Analysis. Pediatr Res 55(4): 478A, April 2004
54. Ambalavanan N, AC Ross, WA Carlo. C-Reactive Protein
Predicts Death/BPD in Extremely Low Birth Weight (ELBW) Infants. Pediatr Res
55(4): 499A, April 2004
55. Ambalavanan
N, A Bulger, J Murphy-Ullrich, PG Anderson,
S Oparil, YF Chen. Stimulatory
Effect of Chronic Hypoxia on Extracellular Matrix Molecule Expression in the
Neonatal Mouse Lung Is Partially Dependent on Endothelin-1 (ET-1). Pediatr Res
55(4): 499A, April 2004
56. Ambalavanan
N, JE Tyson, KA Kennedy, N Hansen, BR Vohr, LL Wright, WA Carlo, for the
NICHD Neonatal Research Network. Does Vitamin A Supplementation
Affect Long-Term Neurodevelopment in Extremely Low Birth Weight (ELBW) Infants?
Pediatr Res 55(4): 504A, April 2004
57. Ambalavanan N,
J Murphy-Ullrich, A Bulger, S
Oparil, Y-F Chen. Matrix Metalloproteinase-2 Contributes to
Pulmonary Alveolar Development and is Essential for Pulmonary Arterial
Remodeling in the Newborn Mouse. [presented at Pediatric Academic Societies’ Meeting
2005]
58. Ambalavanan N,
J Murphy-Ullrich, A Bulger, S
Oparil, Y-F Chen. Fibronectin Decreases with Chronic Hypoxia in
Neonatal Mouse Lung but Increases in Adult Mouse Lung. [presented at Pediatric
Academic Societies’ Meeting 2005]
59. Ambalavanan N, C Roane, WA
Carlo. A Masked
Randomized Controlled Feasibility Trial of Nitric Oxide Administration by
Oxygen Hood.
[presented at Pediatric Academic Societies’ Meeting 2005]
60. James M L, AC Ross, A Bulger, N Ambalavanan. Synergistic
Effect of Vitamin A and Retinoic Acid in Reducing Neonatal Hyperoxic Lung
Injury. [presented
at Pediatric Academic Societies’ Meeting 2005]
61. Fabres JG, N Ambalavanan, V Phillips, G Howard, WA Carlo. PaCO2
Levels and Intraventricular Hemorrhage in Preterm Infants[presented
at Pediatric Academic Societies’ Meeting 2005]
62. El-Ferzli
GT, N Ambalavanan, A Bulger, JB Philips III. A Novel Gas Exchange Assist
Device in a Model of Neonatal Pulmonary Hypertension [presented at Pediatric
Academic Societies’ Meeting 2005]
63. J
Gee, N Ambalavanan, J Gould, WA Carlo. Mortality and Morbidities in Very Low Birth
Weight Infants by Month of Birth in an Academic Neonatal Intensive Care Unit [presented at Pediatric
Academic Societies’ Meeting 2005]
64. Ambalavanan
N, Van Meurs KP, the NICHD NRN. Predictors of Death/BPD in
Preterm Infants with Respiratory Failure[presented at Pediatric Academic
Societies’ Meeting 2006]
65. Ambalavanan
N, Shankaran S, Hypothermia Subcommittee of the NICHD NRN. A Scoring System for Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
[presented at Pediatric Academic Societies’ Meeting 2006]
66. Ambalavanan
N, Shankaran S, Hypothermia Subcommittee of the NICHD NRN. Prediction of Prognosis in Neonatal Hypoxemic-Ischemic Encephalopathy
(HIE) by Classification and Regression Tree (CART) Analysis) [presented at
Pediatric Academic Societies’ Meeting 2006]
67. El-Ferzli
GT, Ambalavanan N, Bulger A, Philips JB III. A Novel Gas Exchange Assist Device in Juvenile Porcine Acute Lung
Injury[presented at Pediatric Academic Societies’ Meeting 2006]
68. Ambalavanan N, Hagood JS, MacEwen MW, Murphy-Ullrich J,
Oparil S, Chen Y-F. Thy-1 Deficiency Leads to Increased TGF-beta Activation and
a Delay in Alveolar Development. (presented at American Thoracic Society
Meeting, 2006)
69. Ambalavanan N, Hagood JS, Murphy-Ullrich J, Bulger A,
Oparil S, Chen Y-F. Inhibition of TGF-Beta Receptor Signaling Attenuates
Neonatal Hypoxia-Induced Pulmonary Arterial Remodeling (presented at American
Thoracic Society Meeting, 2007)
70. Ambalavanan
N, for the NICHD NRN. Cytokines
Associated with BPD/Death in Extremely Low Birth Weight Infants: A Role for
T-Lymphocytes? (presented at the Pediatric Academic
Societies’ Meeting, 2007)
71. Ambalavanan N, Hagood JS, Murphy-Ullrich J, Bulger A, Oparil S, Chen
Y-F. TGF-Beta in Neonatal Hypoxia-Induced
Pulmonary Arterial Remodeling and Inhibition of Alveolar Development. (presented at the Pediatric Academic Societies’ Meeting, 2007)
72. Ambalavanan N, Nicola T, Hagood J, Bulger A, Oparil S, Chen Y-F.
Hypoxia-induced changes in transforming growth factor-beta signaling in the
newborn mouse lung. (presented at the American Thoracic Society Meeting, May
2008)
73. Ambalavanan N, Nicola T, Hagood J, Bulger A, Oparil S, Chen YF.
Alterations in transforming growth factor-beta signaling under hypoxic
conditions in the newborn mouse lung. (presented at the Pediatric Academic
Societies’ Meeting, May 2008)
74. Ambalavanan N, Walsh M, and the NICHD Neonatal Research Network. Factors Contributing to Inter-Center Differences in
Rates of Bronchopulmonary Dysplasia or Death in Very Low Birth Weight Infants. (presented at the Pediatric Academic Societies’ Meeting,
May 2008)
75. Maheshwari A, Ambalavanan N, Smythies LE, Nicola T, Smith PD, Ohls RK. Developmental
Deficiency of TGF-β Predisposes the Premature Neonate to Necrotizing
Enterocolitis. (presented at the Pediatric Academic Societies’ Meeting, May
2008)
76. Magouirk J, Peralta-Carcelen, Edwards S,
Phillips V, Dimmitt R, Ambalavanan N.
Factors Associated with Mode of Immediate Postnatal Feeding and at 2 Weeks of
Age. (presented at the Pediatric Academic Societies’ Meeting, May 2008)
77. Varisco BM, Hagood JS, Ambalavanan N. Thy-1 Shedding is Important in
the Development of Bronchopulmonary Dysplasia. (presented at the Pediatric Academic
Societies’ Meeting, May 2008)
78. McKee L, Fabres J, Peralta M,
Howard G, Carlo W, Ambalavanan N. PaCO2 Levels and Neurodevelopment
in Premature Infants. (presented
at the Pediatric Academic Societies’ Meeting, May 2008)
79. Ambalavanan N, Nicola T, James M, Bulger A, MacEwen M,
Hagood JS. Hypoxia Reduces Thy-1 in
Newborn Lung, Which May Contribute to a BPD Phenotype.
(presented at the American Thoracic Society Meeting, May 2009)
80. Ambalavanan N, D Hougaard, K Skogstrand, D Schendel, P
Thorsen, and The Cytokine Subcommittee. Serum Cytokines and Post-Hemorrhagic
Ventricular Dilation (PHVD) in Extremely Low Birth Weight (ELBW) Infants.
(presented at the Pediatric Academic Societies’ Meeting, May 2009)
81. Ambalavanan N and GDB Subcommittee for the NICHD
Neonatal Research Network (NRN). Outcome Trajectories in Extremely Low Birth
Weight (ELBW) Infants. (presented at the Pediatric Academic Societies’ Meeting,
May 2009)
82. Ambalavanan N, T Nicola, M James, A Bulger, M MacEwen,
JS Hagood. Hypoxia Reduces
Thy-1 in Newborn Lung, Increasing TGF-[beta] Activation and Contributing to a
BPD Phenotype (presented at the Pediatric Academic
Societies’ Meeting, May 2009)
Poster exhibits (only first author posters
listed):
1. Nitric oxide donors inhibit
neonatal pulmonary artery smooth muscle cell proliferation: SPR, San Diego, CA, May 1995
2. Hypoxia increases vascular
endothelial growth factor production by neonatal pulmonary artery smooth muscle
cells: SPR, San Diego, CA, May 1995
3. The effect of pH on neonatal
pulmonary artery smooth muscle and endothelial cell proliferation: SPR, San Diego, CA, May 1995
4. Hypoxia-mediated release of
peptide growth factors from neonatal pulmonary artery smooth muscle cells: PAS
(Pediatric Academic Societies Annual Meeting), Washington, DC, May 1997
5. Does a heme protein regulate
hypoxia-mediated changes in neonatal pulmonary artery smooth muscle cell
proliferation?: PAS (Pediatric Academic Societies Annual Meeting), Washington, DC, May 1997
6. Regulation of neonatal
pulmonary artery smooth muscle cell proliferation by nitric oxide: PAS
(Pediatric Academic Societies Annual Meeting), Washington, DC, May 1997
7. Prediction of neurologic
morbidity and its determinants in ELBW infants: PAS (Pediatric Academic
Societies Annual Meeting), New Orleans, LA, May 1998
8. Hypoxia-mediated alterations
of signal transduction pathways in neonatal pulmonary artery smooth muscle
cells: PAS (Pediatric Academic Societies Annual Meeting), New Orleans, LA, May 1998
9. Cigarette smoke extract
causes non-apoptotic cell death in neonatal vascular smooth muscle cells: PAS
(Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 1999
10. Nitric oxide administration
by oxygen hood in neonatal pulmonary hypertension. PAS (Pediatric Academic
Societies Annual Meeting), Boston, MA, May 2000
11. Endothelin-A receptor
blockade in neonatal pulmonary hypertension. PAS (Pediatric Academic Societies
Annual Meeting), Baltimore, MD, April-May 2001
12. Retinol induces apoptosis
and release of peptide growth factors from neonatal lung cells. PAS (Pediatric
Academic Societies Annual Meeting), Baltimore, MD, April-May 2001
13. A randomized controlled
trial of three vitamin A dosing regimens in extremely low birth weight infants.
PAS (Pediatric Academic Societies Annual Meeting), Baltimore, MD, May 2002
14. Peptide Growth
Factors In Tracheal Aspirates Of Mechanically Ventilated Preterm Neonates. ATS
(American Thoracic Society), Atlanta, GA, May 2002
15. Endothelin-A
receptor blockade prevents and reverses neonatal hypoxic pulmonary vascular
remodeling. PAS
(Pediatric Academic Societies Annual Meeting), Seattle, WA, May 2003
16. Hypoxia
increases matrix metalloproteinase-2 in the neonatal pulmonary vasculature. PAS (Pediatric Academic
Societies Annual Meeting), Seattle, WA, May 2003
17. Transthyretin
and the Retinol Binding Protein / Transthyretin Molar Ratio in Extremely Low
Birth Weight (ELBW) Infants. PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 2004
18. Early
Prediction of Poor Outcome in Extremely Low Birth Weight (ELBW) Infants by Classification
and Regression Tree Analysis. PAS (Pediatric Academic Societies Annual Meeting), San Francisco, CA, May 2004
19. C-Reactive
Protein Predicts Death/BPD in Extremely Low Birth Weight (ELBW) Infants. PAS (Pediatric Academic
Societies Annual Meeting), San Francisco, CA, May 2004
20. Stimulatory
Effect of Chronic Hypoxia on Extracellular Matrix Molecule Expression in the
Neonatal Mouse Lung Is Partially Dependent on Endothelin-1 (ET-1). PAS (Pediatric Academic
Societies Annual Meeting), San Francisco, CA, May 2004
21. Matrix Metalloproteinase-2
Contributes to Pulmonary Alveolar Development and is Essential for Pulmonary
Arterial Remodeling in the Newborn Mouse.
[poster symposium] Pediatric Academic Societies’ Meeting, Washington, DC, May
2005
22. Fibronectin Decreases with
Chronic Hypoxia in Neonatal Mouse Lung but Increases in Adult Mouse Lung. Pediatric Academic
Societies’ Meeting, Washington, DC, May
2005
23. A Masked Randomized
Controlled Feasibility Trial of Nitric Oxide Administration by Oxygen Hood. Pediatric Academic
Societies’ Meeting, Washington, DC, May
2005
24. Predictors
of Death/BPD in Preterm Infants with Respiratory Failure. Pediatric Academic
Societies’ Meeting, San
Francisco, CA, Apr-May
2006
25. A Scoring
System for Neonatal Hypoxic-Ischemic Encephalopathy (HIE). Pediatric Academic
Societies’ Meeting, San
Francisco, CA, Apr-May
2006
26. Prediction
of Prognosis in Neonatal Hypoxemic-Ischemic Encephalopathy (HIE) by
Classification and Regression Tree (CART) Analysis. Pediatric Academic
Societies’ Meeting, San
Francisco, CA, Apr-May
2006
27. Alterations in transforming growth
factor-beta signaling under hypoxic conditions in the newborn mouse lung.
Pediatric Academic Societies’ Meeting, Honolulu, HI, May 2008
28. Factors Contributing to Inter-Center Differences in
Rates of Bronchopulmonary Dysplasia or Death in Very Low Birth Weight Infants. Pediatric Academic Societies’ Meeting, Honolulu, HI, May 2008
29. Hypoxia Reduces Thy-1 in Newborn Lung, Which May
Contribute to a BPD Phenotype. Presented at the
American Thoracic Society Meeting, San Diego, CA, May 2009
30. Serum Cytokines and Post-Hemorrhagic
Ventricular Dilation (PHVD) in Extremely Low Birth Weight (ELBW) Infants.
Presented at the Pediatric Academic Societies’ Meeting, Baltimore, MD, May 2009
Oral Presentations
(only first author presentations listed):
National/International
1. Prediction of extremely low
birth weight (ELBW) neonatal mortality by neural networks and logistic
regression: SPR 1999 (Pediatric Academic Societies Annual Meeting), San Francisco, CA.
2. Prediction of mortality in
extremely low birth weight (ELBW) infants. SPR 2001 (Pediatric Academic
Societies Annual Meeting), Baltimore, MD.
3. Does
Vitamin A Supplementation Affect Long-Term Neurodevelopment in Extremely Low
Birth Weight (ELBW) Infants? PAS 2004 (Pediatric Academic Societies Annual
Meeting), San Francisco, CA
4. Thy-1 deficiency leads to increased
TGF-beta activation and a delay in alveolar development. American Thoracic
Society Meeting, May 2006; MiniSymposium
on Molecular Mechanisms of Lung Development
5. Cytokines Associated with BPD/Death in Extremely Low
Birth Weight Infants: A Role for T-Lymphocytes? PAS
2007 (Pediatric
Academic Societies Annual Meeting), Toronto, Canada
6. Inhibition of TGF-beta receptor signaling
attenuates neonatal hypoxia-induced pulmonary arterial remodeling. American
Thoracic Society Meeting, 2007; MiniSymposium
on Molecular Biology of Neonatal Chronic Lung Disease
7. Outcome Trajectories in Extremely Low
Birth Weight (ELBW) Infants. Pediatric Academic Societies’ Meeting, Baltimore, MD, May 2009
Local/Regional
1.
The Effect of pH on Neonatal Pulmonary Artery Smooth Muscle and
Endothelial Cell Proliferation: SSPR 1995 (Southern Society of Pediatric
Research) (New Orleans, LA) Awarded the “Trainee travel award”.
2.
Hypoxia-mediated release of peptide growth factors from neonatal
pulmonary artery smooth muscle cells: SSPR 1997, New Orleans, LA. Finalist
for the Basic Science Young
Investigator award.
3.
Hypoxia-mediated alterations of signal transduction pathways in
neonatal pulmonary artery smooth muscle cells: SSPR 1998, New Orleans, LA. Finalist
for the Basic Science Young Investigator award.
4.
Nitric oxide donors inhibit neonatal pulmonary artery smooth muscle
cell proliferation: Mead Johnson Southeastern Conference on
Perinatal Research (Islamoralda, Florida) March 1995
5.
Nitric oxide donors inhibit neonatal pulmonary artery smooth muscle
cell proliferation: Alabama Academy of Sciences 72nd annual meeting, UAB, March 16, 1995
6.
Hypoxia increases vascular endothelial growth factor production by
neonatal pulmonary artery smooth muscle cells: Alabama Academy of Sciences 72nd
annual meeting, UAB, March 16, 1995
7.
Nitric oxide administration by oxygen hood in neonatal pulmonary
hypertension: SSPR 2000 (New Orleans. LA). Awarded the Basic Science Young Investigator award.
8.
ATP-gated potassium channels in neonatal pulmonary hypertension: SSPR
2000 (New Orleans. LA).
9.
Retinol induces apoptosis and release of basic FGF from neonatal
pulmonary endothelial and smooth muscle cells. SSPR 2001 (New Orleans. LA).
10.
Endothelin –A receptor blockade in neonatal pulmonary hypertension.
SSPR 2001 (New Orleans. LA).
11.
Peptide growth factors in tracheal aspirates of mechanically ventilated
preterm neonates. SSPR 2002 (New Orleans. LA).
12.
Endothelin-A receptor blockade in neonatal hypoxic pulmonary
vascular remodeling. SSPR 2003 (New Orleans. LA).
Invited workshops
1.
Workshop on Neonatal Ventilation. BIRDEM, Dhaka, Bangladesh. February 03-06, 2003.
2.
Workshop on Neonatal Ventilation. Neonatal Unit, Dept of Pediatrics,
PGIMER, Chandigarh, India. February
7-9, 2003
3.
Workshop on Neonatal Ventilation. Vijaya Health Centre, Chennai (Madras), India. February 12, 2003
4.
NICHD/FDA Newborn Drug Development Initiative (NDDI) Workshop. Baltimore, MD. March
29-30, 2004.
5.
NICHD Improving Pediatric Therapeutics Through the Best Pharmaceuticals
for Children Act of 2002. Washington, DC. May 16, 2005
Invited lectures/moderator
at international courses and meetings
1.
Invited lectures on “Mechanical Ventilation in Respiratory Distress
Syndrome” and “High Frequency Ventilation in PPHN”. 1er.
Congreso Magno Internacional de Neonatologia de la Clinicia de Especialidades
de la Mujer. Mexico City, Mexico. Nov 14-16, 2001.
2.
Invited lectures on “New Advances in Neonatal Resuscitation”, “The Term
Neonate with Respiratory Distress”, and “Kernicterus: A Re-emerging Problem?”. 80 Simposio Internacional de Actualización Pediátrica Dr. Carlos
Gianantonio. Buenos Aires, Argentina. May 22-24, 2003
3.
Invited lecture on “Surfactant therapy”. IIIrd National CME Programme in Neonatology. New Delhi,
India. Oct 10-12, 2003
4.
Moderator for
session on “Bronchopulmonary Dysplasia: Clinical and Experimental Insights” at
the Pediatric Academic Societies’(PAS) meeting, San Francisco, CA. May 2004
5.
Moderator for
session on “Neonatal Medicine: Clinical Trials I” at the Pediatric Academic
Societies’(PAS) meeting, San Francisco, CA. Apr-May 2006
6.
Invited lecture on “Persistent Pulmonary Hypertension of the Newborn”.
Regional Pediatric Conference, Fuzhou, China. November 8, 2006
7.
Invited lecture on “Persistent Pulmonary Hypertension of the Newborn”.
Conference of Chinese Neonatologists, Shanghai, China. November 10, 2006
8.
Invited lecture on “Selecting Candidates for Cooling: The Role of Early
Perinatal Factors”. Section of Perinatal Pediatrics Program, American Academy of Pediatrics National
Conference and Exhibition, San Francisco, CA. Oct 27, 2007
9.
Invited lectures
on “New uses of surfactant in preterm and term infants”, “Synchronized
ventilation”, and “High frequency ventilation and nitric oxide”. XII Curso
Taller Internacional de Avances en Cuidados Intensivos Neonatales. Lima,
Peru. Nov 26-27, 2007.
10.
Moderator for
session on “What’s New - BPD” at the Pediatric Academic Societies’(PAS)
meeting, Honolulu, Hawaii, May 3, 2008
Invited lectures/moderator/major
role at local/regional courses and meetings (does not include local pediatric
and perinatal grand rounds of which there are one to two every year)
1.
Principles of neonatal mechanical ventilation. First Coast Symposium, Jacksonville, FL. May 11, 1998.
2.
Gentle ventilation of the neonate. Collaborative Neonatal-Perinatal
Educational Conference, New York University School of Medicine, New York, NY. June 18, 1999
3.
Pain management and sedation in the NICU. 4th Annual Midwest
Critical Care Symposium for Neonatology, Children’s Hospital Medical Center, Cincinnati, OH. Nov 11, 2000
4.
Moderator for session on Pulmonary Hypertension at “Vascular Biology
and Hypertension 15th Annual Symposium” organized by
the Vascular Biology and Hypertension Program at UAB, Destin, FL. October 7-10,
2004
5.
Effects of hypoxia on the vasculature and extracellular matrix of the
newborn lung. Cell Adhesion and Matrix Research Seminar. UAB, Birmingham, AL. December 14, 2004
6.
Pulmonary hypertension and pulmonary vascular remodeling in the newborn
infant. Vascular Biology and Hypertension Program Seminar. UAB, Birmingham, AL. January 7, 2005
7.
Prediction of outcomes in critically ill children. Child Health
Investigative Forum (CHIF). UAB, Birmingham, AL. August 19, 2005
8.
Probiotics in premature infants. Alabama Neonatology Network
Conference. UAB, Birmingham, AL. September 1, 2005
9.
Inhaled Nitric Oxide in premature infants. Alabama Neonatology Network
Conference. UAB, Birmingham, AL. September 1, 2005.
10.
Moderator for 30th Annual Southeastern Conference on
Perinatal Research, February 6-8, 2006
11.
Predicting outcome of infants diagnosed with hypoxemic-ischemic
encephalopathy. Alabama Neonatology Network
Conference. UAB, Birmingham, AL. April 27, 2006.
12.
Effects of hypoxia on the newborn lung. Alabama Neonatology Network Conference.
UAB, Birmingham, AL. November 2, 2006.
13.
Vitamin A in preterm infants – from bedside to bench. Child Health
Investigative Forum (CHIF). UAB, Birmingham, AL. November 3, 2006
14.
Effects of hypoxia on the newborn lung. Neonatology Research Seminar.
Children’s Hospital of Philadelphia, Philadelphia, PA. February
23, 2007
15.
Lead reviewer for Perinatal Medicine, Southern Society for Pediatric
Research, 2008
16.
Effects of hypoxia on the newborn lung. Vascular Biology and
Hypertension Program Seminar. UAB, Birmingham, AL. October 19, 2007
17.
Effects of hypoxia on the newborn lung. Research Seminar. University of Texas – SouthWestern (UTSW), Dallas, TX. December 13, 2007
18.
How can we predict outcomes in critically ill infants?. Jerry Elliott
Memorial Lecture. 32nd Southeastern Conference on Perinatal Research
(Mead Johnson Nutritionals). Key Largo, FL. February 12,
2008
19.
Prediction of outcomes in critically ill infants. Department of
Pediatrics Grand Rounds, University of Illinois at Chicago, September 3, 2008
20.
TGF-beta regulates effects of hypoxia on the newborn lung. Vascular
Biology and Hypertension Program Seminar. UAB, Birmingham, AL. January 16, 2009
21.
Neonatal cooling:
Picking the right patient. NEO 2009. The Conference for Neonatology. Lake Buena Vista, FL. March 1, 2009.
22.
“Current outcomes
and newer therapies for infants treated with hypothermia for HIE” and “Patient
Selection Criteria and Consideration for Implementing a Cooling Program”. Innovations in the Care of the Critically Ill
Neonate. San Antonio, TX. May 14 and 15, 2009
23.
Retinoids in lung development and injury: from bedside to bench. Vascular Biology and
Hypertension Program Seminar. UAB, Birmingham, AL. September 29, 2009
MISCELLANEOUS:
Mentorship (See
Table at end of CV for full table of mentored candidates)
Pre-doctoral candidates:
1. Outside Research Director
for Waldemar F. Carlo’s thesis research project, Harvard University Biology
Undergraduate Programs, 1999-2000 (abst.
22; publ. 7, 9). Project title: Effects of cigarette smoke extract on
neonatal pulmonary artery smooth muscle cells. Current position: Pediatric cardiology
fellowship, Baylor College of Medicine, Houston, TX
2. Research mentor for Linda Oniah, Ronald E. McNair
Post-Baccalaureate Achievement Program, June –August 2001 (abst. 41). Project title: Development of a chicken embryo model to
simulate the effects of maternal diabetes. Current position: Dental School
3. Research mentor for Masheika James, Ronald E. McNair
Post-Baccalaureate Achievement Program, June –August 2003 (abst. 38, 60). Project title: Retinoids and apoptosis in hyperoxic
lung injury. Current position: Graduate program, UAB
4. Research mentor for Masheika
James, PhD (Molecular and Cellular Pathology) Program, 2007-present. Project
title: Retinoids and Hyperoxic lung injury. Current position: Graduate program,
UAB (Funded by NIH F31 Predoctoral grant
– percentile score 4.0)
Post-doctoral candidates:
1. Clinical Research Mentor for Bridget A. Cobb, Fellow
in Neonatology 2000-2003. Current position: Neonatologist in private practice, Atlanta, GA (Publication 14 in “Pediatrics”; abst 40, 43).
2. Clinical Research Mentor for Eduardo Broitman,
Fellow in Neonatology 2001-2004. Current position: Assistant Professor in the Department of Pediatrics, University of
Concepción, Concepción, Chile (Publication
29 in “J Pediatr”; abst. 52).
3. Clinical Research Mentor for Jorge Fabres, Fellow in
Neonatology 2002-2005. Current position: Assistant Professor, Neonatology Unit,
Department of Pediatrics, Universidad Catolica de Chile, Santiago, Chile (Publication 27 in “Pediatrics”; abst. 61).
4. Basic Research Mentor for George El-Ferzli, Fellow
in Neonatology 2002-2005. Current position: Assistant Professor, Division of
Neonatology, UAB (abst. 62; PHA grant 2005-2006; Publications
47, 48 in “Pediatric Research”).
5. Clinical Research Mentor for Lara McKee, Fellow in
Neonatology 2005-2008. Current position: Neonatologist, Nashville, TN (Publication 46 in “J Pediatr”; abst. 78)
6. Clinical Research Mentor for Thomas Soltau, Fellow in Neonatology
2006-2009. Current position: Assistant Professor, Department of Pediatrics, UAB
(Publication 37 in “Pediatrics”; abst.
63).
7. Basic Research Mentor for
Teodora Nicola, Post-doc in laboratory, 2007-2009. Current position: Research
Associate. (Publications 34, 42 so far).
Internet-related work
1. Author of the chapter on
“Neonatal Fluids, Electrolytes, and Nutrition” on emedicine at http://emedicine.medscape.com/article/976386-overview
2. Author of the chapter on
“Bronchopulmonary Dysplasia” on emedicine
at: http://emedicine.medscape.com/article/973717-overview
3. Collection of neonatology
teaching files at personal website http://home.sprynet.com/~ambal/neonatal.htm
4. Carlo WA, Ambalavanan N:
Conventional Mechanical Ventilation: Traditional and New Strategies. Pediatr Rev (Online) 20(12):e117-e126, Dec 1999 http://pedsinreview.aapjournals.org/cgi/content/full/20/12/e117
5. Collection of grant-related
information at website: http://www.dpo.uab.edu/~ambal/grants.htm
REFEREE / REVIEWER FOR
JOURNALS (in alphabetical order)
1. Acta Paediatrica
2. American Journal of
Obstetrics and Gynecology
3. American Journal of
Perinatology
4. American Journal of
Physiology Lung Cell Mol Physiol
5. American Journal of
Respiratory and Critical Care Medicine (AJRCCM; the Blue journal)
6. Archives of Pediatrics and
Adolescent Medicine
7. Artificial Intelligence in
Medicine (AIIM)
8. Biology of the neonate (now
“Neonatology”)
9. Biomechanics and Modeling in
Mechanobiology
10. BMC Pediatrics
11. Histology and Histopathology
12. Indian Pediatrics
13. Intensive Care Medicine
14. Journal of Hypertension
15. Journal of
Neonatal-Perinatal Medicine
16. Journal of Pediatrics
17. Journal of the American
Medical Association (JAMA)
18. Journal of Vascular Research
19. Maternal and Child Health
Journal
20. Nutrition
21. Pediatric Drugs
22. Pediatric Pulmonology
23. Pediatrics
24. Pediatrics International
25. PLoS ONE
26. Respiratory Research
27. The American Journal of
Clinical Nutrition
28. The Journal of Nutrition
29. World Journal of Pediatrics
SOFTWARE
ANNE
(Automated NeoNatal Entries) database software developed for PGIMER, Chandigarh (Sept 1993) in dBase IV
programming language: Forms based user-friendly database for storing, analyzing
neonatal patient data, and printing patient discharge summaries.
Pre- and Postdoctoral Trainees for the Past
Ten Years
|
Faculty Member
Past and Current
Trainees
|
Pre
or Post
|
Training Period
|
Prior Academic Degree(s)
|
Prior Academic Degree
Year(s)
|
Prior Academic Degree
Institutions(s)
|
Title of Research Project
|
Current Position (past trainees)
Source of Support (current trainees)
|
|
Waldemar F. Carlo
|
Pre
|
1999-2000
|
BS
|
1996-2000
|
Harvard
University
|
Effects of cigarette smoke extract on neonatal pulmonary
artery smooth muscle cells
|
Pediatric Cardiology Fellowship, Baylor College
of Medicine, Houston,
TX
|
|
Linda Oniah
|
Pre
|
2001
|
BS
|
1998-2002
|
University
of Alabama at Birmingham
|
Development of a chicken embryo model to simulate the
effects of maternal diabetes
|
Dentist
|
|
Masheika James
|
Pre
|
2007-present
|
MS
|
2002-2006
|
University of Alabama at Birmingham
|
Retinoids and hyperoxic lung injury
|
NIH F31
|
|
Bridget A. Cobb
|
Post
|
2000-2003
|
MD
|
1993-1997
|
University
of Alabama at Birmingham
|
Gastric residuals and their relationship to necrotizing
enterocolitis in very low birth weight infants
|
Neonatologist, Atlanta, GA
|
|
Eduardo Broitman
|
Post
|
2001-2004
|
MD
|
1989-1996
|
University of Concepcion, Chile
|
Cranial ultrasound in relation to long-term
neurodevelopmental outcome in preterm infants
|
Assistant Professor in the Department of Pediatrics, University
of Concepción, Concepción,
Chile
|
|
Jorge Fabres
|
Post
|
2002-2005
|
MD
|
1983-1990
|
Universidad
de Chile, Chile
|
Arterial carbon
dioxide pressure and severe intraventricular hemorrhage in preterm infants
|
Assistant Professor, Neonatology Unit, Department of
Pediatrics, Universidad Catolica de Chile, Santiago,
Chile
|
|
George El-Ferzli
|
Post
|
2002-2005
|
MD
|
1989-1994
|
American University
of Beirut, Lebanon
|
A novel lung assist device reduces pulmonary arterial
pressures and improves oxygenation in a neonatal porcine model of pulmonary
hypertension
|
Assistant Professor, Division of Neonatology, Department
of Pediatrics,
University of Alabama
at Birmingham
|
|
Thomas Soltau
|
Post
|
2006-2009
|
MD
|
1999-2003
|
Medical College
of Georgia, GA
|
Mortality and morbidity by month of birth of neonates
admitted to an academic neonatal intensive care unit
|
Assistant Professor, Division of Neonatology, Department
of Pediatrics,
University of Alabama
at Birmingham
|
|
Katarzyna Dabrowska
|
Post
|
2007-2009
|
MD
|
1986-1992
|
Medical
Academy in Bialystok,
Poland
|
Risk factors for adverse outcome in near-term infants
|
Department of Pediatrics Fellowship Training Funds
|
|
John Kelleher
|
Post
|
2008-present
|
MBBChBAO, MRCP
|
1994-1999
|
Royal College of Surgeons and Physicians, Dublin, Ireland
|
Risk factors for hearing loss in extremely low birth
weight infants
|
Department of Pediatrics Fellowship Training Funds
|
|
Brian Varisco
|
Post
|
2007-present
|
MD
|
2000-2004
|
Medical College
of Georgia, GA
|
Thy-1 and bronchopulmonary dysplasia
|
Dixon
Fellowship
|
|
Teodora Nicola
|
Post
|
2007-2009
|
PhD
|
1996-1999
|
German
Cancer Research
Center, Heidelberg,
Germany
|
Hypoxia and TGF-beta in newborn lung
|
Research Associate, Division of Neonatology, Department of
Pediatrics,
University of Alabama
at Birmingham
|